Prognostic value of arterial/alveolar oxygen tension ratio (a/APO2) in acute pulmonary embolism

Circulation Journal : Official Journal of the Japanese Circulation Society
Jen Te HsuChang Min Chung


Because the arterial/alveolar oxygen tension ratio (a/APO2) is relatively constant throughout the entire range of fractional inspired oxygen concentration (FiO2), its use in determining the prognosis of acute pulmonary embolism (APE) was investigated. This study retrospectively assessed 202 consecutive patients with APE confirmed by computed tomography or high probability lung scintigraphy. All patients underwent initial arterial blood gas analysis during the first 24 h of admission. Receiver-operating characteristic analyses were performed to determine the a/APO2 cut-off value for predicting 30-day death or 30-day composite events. Cut-off values for a/APO2 were used to determine stability in all patients and 2 subgroups (0.49 for all patients; 0.49 for FiO2 =0.21; 0.46 for FiO2 >0.21). Using the cut-off value of a/APO2 <0.49 for predicting 30-day death, the negative predictive value (NPV) was 90%, and the positive predictive value (PPV) was 30.3%. For the 30-day composite end point, the NPV was 81.3%, and the PPV was 40.9%. Excluding massive APE, the a/APO2 also had high NPV and moderate PPV in predicting short-term prognosis. This study additionally demonstrated a linear relationship between platelet count and a/APO2. The cu...Continue Reading


Jul 1, 1976·Critical Care Medicine·J ModigJ Lundström
Jul 1, 1975·Journal of Applied Physiology·S E Levy, D H Simmons
May 1, 1989·The American Review of Respiratory Disease·K S KapitanK M Moser
Dec 1, 1985·Chest·Y HuetD Mathieu
Aug 1, 1982·The Journal of Clinical Investigation·T UtsonomiyaH B Hechtman
Jan 1, 1984·Japanese Circulation Journal·T KuniedaT Yoshioka
Nov 1, 1983·Critical Care Medicine·L V PerisA Arnau
Jul 1, 1983·The American Review of Respiratory Disease·G E D'AlonzoD R Dantzker
Jan 1, 1994·The Journal of Clinical Investigation·R Rodriguez-RoisinJ Roca
Jan 1, 1997·Critical Care Medicine·M S Gowda, R A Klocke
Nov 14, 1997·Journal of the American College of Cardiology·Samuel Z Goldhaber
Jan 29, 2000·Annals of Emergency Medicine·J A KlineE G Israel
Feb 15, 2001·Echocardiography·Ary Ribeiro
Jul 23, 2003·Anesthesia and Analgesia·Greg Stratmann, George A Gregory
Nov 5, 2003·Circulation·Nils Kucher, Samuel Z Goldhaber
Jan 14, 2004·Chest·P S SriramJohn G Mastronarde
Mar 31, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Stavros Konstantinides
Jun 17, 2004·Seminars in Vascular Medicine·A Torbicki, P Pruszczyk
Oct 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi MorioMasaaki Osegawa
May 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Masami KosugeSatoshi Umemura
Nov 28, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Jen Te HsuChang Min Chung


Sep 13, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Jen Te HsuChinae Miyamoto
Dec 2, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Takeshi YamamotoKeiji Tanaka
Aug 4, 2009·Vascular Health and Risk Management·Luca MasottiPatrick Ray
Aug 21, 2009·Journal of Veterinary Emergency and Critical Care·Robert GoggsDaniel L Chan
Aug 15, 2012·Journal of Hepatology·Emmanuel MelloulJacques Belghiti

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.