Prognostic Value of Blood Urea Nitrogen/Creatinine Ratio for Septic Shock: An Analysis of the MIMIC-III Clinical Database.

BioMed Research International
Didi HanJun Lyu

Abstract

Research has previously been done into the risk factors for mortality in septic shock patients. However, there has been no epidemiological study investigating the effect of the blood urea nitrogen/creatinine ratio (BCR) on the prognosis of critically ill septic shock patients. This study is aimed at determining the relationship between BCR and all-cause mortality in adult septic shock patients. Data were extracted from the MIMIC-III database. The clinical endpoints were 28-, 90-, and 365-day all-cause mortality rates in critically ill septic shock patients. Cox proportional hazards models and subgroup analyses were used to analyze the relationship between BCR quartiles and all-cause mortality in septic shock patients. Receiver operator characteristic (ROC) curves and areas under the ROC curves (AUCs) were calculated to evaluate how accurately BCR predicts the mortality of septic shock patients. Among the 2484 septic shock patients extracted from the database, 619, 563, 677, and 625 fell into the first (<14.4 mg/dL), second (≥14.4 mg/dL and <20.0 mg/dL), third (≥20.0 mg/dL and <27.3 mg/dL), and fourth (≥27.3 mg/dL) quartiles of BCR, respectively. Male and white patients accounted for 53.8% (1336 patients) and 74.8% (1857 patient...Continue Reading

References

Aug 1, 1995·The Annals of Thoracic Surgery·A J HartzW D Johnson
Jan 23, 1997·The New England Journal of Medicine·M J FineW N Kapoor
Apr 18, 2003·The New England Journal of Medicine·Greg S MartinMarc Moss
Feb 3, 2005·JAMA : the Journal of the American Medical Association·Gregg C FonarowUNKNOWN ADHERE Scientific Advisory Committee, Study Group, and Investigators
Oct 11, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Paul R Schloerb, Michael Moncure
Sep 10, 2010·The American Journal of Emergency Medicine·Leng C LinW C Fann
Apr 13, 2011·Archives of Internal Medicine·Bechien U WuPeter A Banks
Aug 20, 2011·Chest·Gagan KumarUNKNOWN Milwaukee Initiative in Critical Care Outcomes Research (MICCOR) Group of Investigators
Feb 16, 2012·Clinical Neurology and Neurosurgery·Jon W SchrockKristin Drogell
Feb 28, 2013·Critical Care Medicine·David F GaieskiBrendan G Carr
Dec 18, 2013·Virulence·Florian B MayrDerek C Angus
Mar 19, 2014·JAMA : the Journal of the American Medical Association·Kirsi-Maija KaukonenRinaldo Bellomo
Apr 10, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoichi TakayaYuhei Kawano
Jun 5, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Nobuyuki Shiba
Feb 19, 2016·Annals of Translational Medicine·Zhongheng Zhang
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Apr 6, 2016·Annals of Translational Medicine·Zhongheng Zhang
May 25, 2016·Scientific Data·Alistair E W JohnsonRoger G Mark
Sep 14, 2017·JAMA : the Journal of the American Medical Association·Chanu RheeUNKNOWN CDC Prevention Epicenter Program
Apr 1, 2012·Clinical Kidney Journal·Shigehiko UchinoDonna Goldsmith
Jun 26, 2018·Lancet·Maurizio CecconiAndrew Rhodes
Feb 13, 2019·Internal Medicine Journal·Kelly ThompsonSimon Finfer
Sep 19, 2019·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Benji WangXiaomei Li
May 19, 2020·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yangpei PengKangting Ji

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