Prognostic value of c-erbB2 expression in breast cancer

Journal of Surgical Oncology
S TsutsuiShinya Oda

Abstract

An overexpression of c-erbB2 has been reported to be associated with a poor clinical outcome in breast cancer, however, its prognostic value remains controversial especially in patients with node negative breast cancer, and regarding the estrogen receptor (ER) status. Immunohistochemical staining for c-erbB2 was performed on the primary breast cancer from 698 Japanese patients with a mean follow-up duration of 54 months. The c-erbB2 expression was positive in 120 (17.2%) of 698 cases, which inversely correlated with the ER status. Both univariate and multivariate analyses indicated the c-erbB2 expression to be a significant prognostic factor for the disease-free survival (DFS) and overall survival (OS), while the same effect was also seen in the patient groups with node negative as well as node positive breast cancer. A univariate analysis also indicated a subgroup with the positive c-erbB2 and negative ER to have both a worse DFS and OS than the other subgroups. The patients with positive c-erbB2 had a significantly worse DFS and OS than the patients with negative c-erbB2 in all patient groups stratified according to the adjuvant therapies, while the prognostic significance of c-erbB2 on DFS was also found in the patients with...Continue Reading

References

Jul 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B A GustersonR Reed
Apr 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D C AllredL Eudey
Aug 19, 1991·International Journal of Cancer. Journal International Du Cancer·F RilkeA Testori
Jul 1, 1990·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J RichnerN E Hynes
Aug 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A K TandonW L McGuire
Mar 1, 1993·British Journal of Cancer·S BianchiS Ciatto
Jan 1, 1993·Breast Cancer Research and Treatment·C C BenzC K Osborne
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R I NicholsonR W Blamey
Oct 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R SeshadriP Kitchen
Oct 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C CarlomagnoS De Placido
Feb 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S SjögrenJ Bergh
Apr 29, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I L AndrulisD McCready
Sep 25, 1998·Journal of the National Cancer Institute·A D ThorE T Liu
Nov 3, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F RévillionJ P Peyrat

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Citations

Nov 25, 2003·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Shinichi TsutsuiShoichi Era
Jun 3, 2005·Journal of Cancer Research and Clinical Oncology·Dao-Hai ZhangRobert E Hewitt
Dec 12, 2003·European Urology·H G van der Poel
Feb 6, 2004·Breast Cancer Research and Treatment·Linda Saxe EinbondI Bernard Weinstein
Oct 23, 2013·Nature Reviews. Clinical Oncology·Naoki NiikuraNaoto T Ueno
Feb 18, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Y H ChoiW K Kim
Feb 22, 2005·Applied Immunohistochemistry & Molecular Morphology : AIMM·Young Choi, Marguerite Pinto
Dec 13, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Leslie C Lai
Aug 1, 2006·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Tatjana Ivković-KapiclKatarina Mastilović
Dec 6, 2006·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Tatjana Ivković-KapiclKatarina Mastilović
Aug 25, 2006·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Hitoshi Tsuda
Mar 29, 2014·Indian Journal of Surgical Oncology·Debarshi JanaSyamsundar Mandal
Mar 13, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·X HanY Xie
Jun 5, 2003·Expert Opinion on Investigational Drugs·Rita NahtaFrancisco J Esteva
Oct 13, 2012·European Journal of Cell Biology·David Denis Sofeu FeugaingManuela Viola
Feb 1, 2003·American Journal of Surgery·Shinichi TsutsuiYoichi Hachitanda
Sep 12, 2002·Expert Opinion on Therapeutic Targets·Ding Cheng YangJonathan F Head
Feb 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Allison W KurianAlan M Garber
Feb 6, 2004·Molecular & Cellular Proteomics : MCP·Jeffrey S RossGabriel N Hortobagyi
Jan 22, 2004·British Journal of Cancer·G P BolandN J Bundred
Jan 28, 2015·Molecular Endocrinology·Marcela A Bennesch, Didier Picard
Nov 14, 2019·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Yifan GuYibao Du
Aug 5, 2003·The Oncologist·Jeffrey S RossKenneth J Bloom
Feb 14, 2020·British Journal of Nursing : BJN·Sarah McCauleyKatherine Ma Rogers
Jul 30, 2015·Oncotarget·David Z Kochan, Olga Kovalchuk
May 12, 2021·Molecular Diagnosis & Therapy·Benedetta PellegrinoCinzia Solinas

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