Prognostic value of c-MET in head and neck cancer: A systematic review and meta-analysis of aggregate data

Oral Oncology
Petr SzturzSandrine Faivre

Abstract

The hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (c-MET) ligand/receptor axis has been implicated in pathogenesis of malignant diseases including squamous cell carcinoma of the head and neck (SCCHN). Overexpression of c-MET has been reported as a common molecular abnormality in SCCHN, although its prognostic and predictive value remains to be validated. We systematically searched literature for studies evaluating c-MET expression on immunohistochemistry in newly diagnosed, non-metastatic SCCHN. The c-MET expressing cases were classified into three categories according to predefined cut-off values for positivity. Our aim was to assess the prevalence of c-MET expression and its relationship with selected clinicopathological variables. Twenty-eight studies with 2019 cases were included. Relative frequencies of c-MET expression above cut-off levels I, II, and III were 81.8%, 63.8%, and 46.2%, respectively. Differences between these three values were statistically significant (p<1.0×10-6). Above cut-off level II, c-MET positivity was associated with worse overall survival (p=4.0×10-6), positive nodal status (p=1.0×10-4), higher disease stage (p=7.0×10-4), older age (p=2.1×10-3), disease recurrence (p=2.0×1...Continue Reading

Citations

Mar 21, 2019·Current Opinion in Oncology·Esma Saada-BouzidJoël Guigay
Sep 13, 2019·Critical Reviews in Clinical Laboratory Sciences·Fatemeh MoosaviOmidreza Firuzi
Aug 20, 2020·Technology in Cancer Research & Treatment·Qili XuQigui Xie
Aug 17, 2019·International Journal of Molecular Sciences·Yi-Ta HsiehWan-Chun Li
Dec 21, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Maria J De HerdtLeendert H Looijenga
Mar 1, 2019·Frontiers in Oncology·Esma Saada-Bouzid, Christophe Le Tourneau
Jan 17, 2020·International Journal of Molecular Sciences·Verena BoschertStefan Hartmann
Sep 5, 2021·International Journal of Oral and Maxillofacial Surgery·J J WuX Gao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.