Prognostic value of cardiac tests in potential kidney transplant recipients: a systematic review

Transplantation
Louis W WangAngela C Webster

Abstract

Whether abnormal myocardial perfusion scintigraphy (MPS), dobutamine stress echocardiography (DSE) or coronary angiography, performed during preoperative evaluation for potential kidney transplant recipients, predicts future cardiovascular morbidity is unclear. We assessed test performance for predicting all-cause mortality, cardiovascular mortality and major adverse cardiac events (MACE). We searched MEDLINE and EMBASE (to February 2014), appraised studies, and calculated risk differences and relative risk ratios (RRR) with 95% confidence intervals (95% CI) using random effects meta-analysis. Fifty-two studies (7401 participants) contributed data to the meta-analysis. Among the different tests, similar numbers of patients experienced MACE after an abnormal test result compared with a normal result (risk difference: MPS 20 per 100 patients tested [95% CI, 0.11-0.29], DSE 24 [95% CI, 0.10-0.38], and coronary angiography 20 [95% CI, 0.08-0.32; P = 0.91]). Although there was some evidence that coronary angiography was better at predicting all-cause mortality than MPS (RRR, 0.69; 95% CI, 0.49-0.96; P = 0.03) and DSE (RRR, 0.72; 95% CI, 0.50-1.02; P = 0.06), noninvasive tests were as good as coronary angiography at predicting cardio...Continue Reading

References

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Citations

Dec 29, 2015·Transplantation Proceedings·A YildizM Gullulu
Nov 1, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Matthew TopelJoe X Xie
Sep 7, 2019·Transplantation·Shaifali SandalMarcelo Cantarovich
Dec 12, 2018·World Journal of Hepatology·Jonathan SolderaAjacio Brandão
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Oct 5, 2019·Clinical Kidney Journal·Federica E PoliMatthew P Graham-Brown
Oct 5, 2017·European Heart Journal Cardiovascular Imaging·Salla HelveTuomo Nieminen
Oct 7, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andras T DeakAlexander R Rosenkranz
Jan 4, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Valeria CantoniAlberto Cuocolo
Aug 24, 2020·JACC. Cardiovascular Imaging·Vasken DilsizianCharles A Herzog
Jan 29, 2021·Clinical and Experimental Nephrology·Jose Jayme G De LimaLuiz A Bortolotto
Jan 10, 2021·Journal of Clinical Medicine·Marina de Cos GomezEmilio Rodrigo Calabia
Mar 6, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Kameel Kassab, Rami Doukky
Jul 3, 2021·Journal of Clinical Medicine·Prasanti Alekhya KottaVassilios Papalois

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