Prognostic Value of Cardiopulmonary Exercise Testing in Heart Failure With Reduced, Midrange, and Preserved Ejection Fraction

Journal of the American Heart Association
Wilson NadruzAmil M Shah

Abstract

This study aimed to compare the independent and incremental prognostic value of peak oxygen consumption (VO2) and minute ventilation/carbon dioxide production (VE/VCO2) in heart failure (HF) with preserved (HFpEF), midrange (HFmEF), and reduced (HFrEF) ejection fraction (LVEF). In 195 HFpEF (LVEF ≥50%), 144 HFmEF (LVEF 40-49%), and 630 HFrEF (LVEF <40%) patients, we assessed the association of cardiopulmonary exercise testing variables with the composite outcome of death, left ventricular assist device implantation, or heart transplantation (256 events; median follow-up of 4.2 years), and 2-year incident HF hospitalization (244 events). In multivariable Cox regression analysis, greater association with outcomes in HFpEF than HFrEF were noted with peak VO2 (HR [95% confidence interval]: 0.76 [0.67-0.87] versus 0.87 [0.83-0.90] for the composite outcome, Pinteraction=0.052; 0.77 [0.69-0.86] versus 0.92 [0.88-0.95], respectively for HF hospitalization, Pinteraction=0.003) and VE/VCO2 slope (1.11 [1.06-1.17] versus 1.04 [1.03-1.06], respectively for the composite outcome, Pinteraction=0.012; 1.10 [1.05-1.15] versus 1.04 [1.03-1.06], respectively for HF hospitalization, Pinteraction=0.019). In HFmEF, peak VO2 and VE/VCO2 slope were ...Continue Reading

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Citations

Feb 13, 2018·European Journal of Heart Failure·Wayne C Levy, Todd F Dardas
Jan 12, 2019·European Journal of Heart Failure·Stefania PaolilloUNKNOWN MECKI Score Research Group (see Appendix)
Jun 21, 2019·PloS One·Daniel ContaiferDayanjan S Wijesinghe
Nov 30, 2019·European Journal of Heart Failure·Sara RovaiUNKNOWN MECKI Score Research Group (see Appendix 1)
Oct 3, 2020·The European Respiratory Journal·Iván CaviedesFelix Herth
Nov 27, 2020·European Journal of Preventive Cardiology·Damiano MagrìMichele Senni
Nov 26, 2019·Journal of Cardiopulmonary Rehabilitation and Prevention·Wesley J TuckerCorey R Tomczak
Feb 5, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Piergiuseppe AgostoniElisabetta Salvioni
Feb 19, 2021·Journal of the American Heart Association·Walter E M RochaWilson Nadruz
Aug 18, 2020·Heart Failure Reviews·Marijana TadicCesare Cuspidi
Mar 28, 2021·ESC Heart Failure·Javier Roibal PravioMaria Generosa Crespo Leiro
May 16, 2021·Journal of Cardiac Failure·Michael F CosianoStephen J Greene
Jun 29, 2021·Current Treatment Options in Cardiovascular Medicine·J Emanuel FinetW H Wilson Tang
Aug 20, 2021·Journal of Applied Physiology·Hanaa ShafiekBorja G Cosio
Jan 14, 2022·Journal of the American Heart Association·Shahryar M ChowdhuryAndrew M Atz

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