Prognostic value of CD44 variant 6 in laryngeal epidermoid carcinomas

Archives of Otolaryngology--head & Neck Surgery
Gülnur GülerOgawa Hiroshi

Abstract

CD44 variant exon 6 (v6) belongs to a family of transmembrane glycoproteins involved in cell adhesion. To determine the prognostic role of CD44v6 in laryngeal cancer and to examine its relation with other clinicopathologic prognostic factors. A retrospective cohort study was designed with 93 laryngeal cancer cases. They were selected randomly from patients treated with laryngectomy between January 1, 1983, and December 31, 1993. Faculty of Medicine, Hacettepe University, Ankara, Turkey. The ages of the patients ranged from 31 to 73 years. Eighty-eight patients were men and 5 were women. Three had stage I, 33 had stage II, 27 had stage III, and 30 had stage IV disease at the time of surgery. Histological sections of tumors and metastatic lymph nodes were reevaluated for several histopathological factors. Sections were stained using anti-CD44v6 monoclonal antibody by immunohistochemical methods. CD44v6 expression was seen only in the lower one third of the normal squamous epithelium but in all layers of dysplasia and in situ carcinoma. Besides a general evaluation of tumor staining, immunostaining was evaluated separately for cell groups located in the center of neoplastic islands (nonbasal cells), at the periphery of the neoplas...Continue Reading

Citations

Aug 10, 2004·Journal of Cancer Research and Clinical Oncology·Francisco J VizosoManuel García-Morán
Apr 17, 2008·Journal of Cancer Research and Clinical Oncology·Houyu ZhaoShixi Liu
Oct 6, 2005·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Banghua LiuLixin Zhu
Jul 15, 2011·Head & Neck·Paul NankivellHisham Mehanna
Jul 13, 2005·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Aly G Saad, Margaret H Collins

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