Prognostic Value of Cervical Nodal Necrosis in Nasopharyngeal Carcinoma: Analysis of 1800 Patients with Positive Cervical Nodal Metastasis at MR Imaging

Radiology
Mei LanTai-Xiang Lu

Abstract

To evaluate the prognostic value of cervical nodal necrosis (CNN) in patients with nasopharyngeal carcinoma (NPC) with magnetic resonance (MR) imaging. This was an institutional review board-approved retrospective study of 1800 patients with newly diagnosed stage T1, 4N1, 3M0 NPC who were treated with definitive radiation therapy, with or without chemotherapy, between January 2007 and December 2009; the requirement to obtain informed consent was waived. MR images were reviewed to assess lymph node status, and patients were divided into CNN and non-CNN groups. The overall survival, disease-free survival, regional relapse-free survival (RRFS), and distant metastasis-free survival (DMFS) were calculated with the Kaplan-Meier method, and differences were compared by using the log-rank test. The incidence of CNN was 44.0% (792 of 1800). After the median follow-up period of 53 months, the 5-year overall survival, disease-free survival, RRFS, and DMFS rates of the CNN and non-CNN groups were 78.8% and 91.8%, 78.2% and 91.2%, 78.6% and 91.8%, and 78.4% and 91.6%, respectively (for all rates, P < .001). The distant metastasis rate was 18.7% (148 of 792) for the CNN group versus 4.6% (46 of 1008) for the non-CNN group (P < .01). Subgroup...Continue Reading

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Citations

Jul 12, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Xin LiMei Shi
Jan 14, 2017·Acta Oto-laryngologica·Jing ZhangLiangfang Shen
Jan 13, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jiang-Yi HeQian Zhong
Aug 30, 2020·Journal of Magnetic Resonance Imaging : JMRI·Huali MaAnnan Dong
May 16, 2020·Surgical and Radiologic Anatomy : SRA·Michael H Zhang, Daniel T Ginat
Aug 23, 2020·Journal of Magnetic Resonance Imaging : JMRI·Chih-Hua Yeh
Oct 8, 2020·Der Radiologe·Frederik Fries
Nov 21, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Shao-Bo LiangXiang-Ying Xu
Mar 30, 2021·Head & Neck·Wai Tong NgAlfio Ferlito
Sep 2, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Shan-Shan YangFang-Yun Xie

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