Abstract
The prognostic weight of histological and biological factors was compared with that of known clinical prognostic factors in a population of 108 consecutive previously untreated patients with head and neck squamous cell carcinoma. Parameters studied were: tumour vascularisation, mitotic index, histological differentiation, nuclear grade, keratinisation, desmoplasia, growth pattern, inflammation, tumour emboli in peripheral vessels, keratins 6, 13, 19 immunohistochemical expression, cytofluorometric ploidy and S-phase. In multivariate analysis (Cox), only age and nodal status had a significant impact on the overall survival, whereas T stage was the only significant factor associated with locoregional failure. The cumulative incidence of metastases was correlated not only with age, T and N stage, but also with histological differentiation. All the other histological and biological factors studied failed to provide further prognostic information. These findings may help to select patients with high metastatic risk.
Citations
Dec 29, 2000·The Laryngoscope·S F HallD Rothwell
Jan 18, 2006·BMC Cancer·Thomas FilliesHorst Buerger
Jul 11, 2006·The Laryngoscope·Eben L RosenthalWenyue Zhang
May 20, 2008·The British Journal of Radiology·Y-H ChenJ C-H Cheng
Mar 22, 2018·Journal of Cancer Research and Clinical Oncology·Silke WemmertBernhard Schick
Feb 6, 2019·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Noriyuki FujimaHiroki Shirato
Mar 9, 2019·Laryngoscope Investigative Otolaryngology·Sarah R AkkinaCarol R Bradford
Aug 13, 2008·The Journal of Laryngology and Otology·F O AgadaJ Greenman
Feb 28, 2008·Head & Neck·Tsung-Lin YangYih-Leong Chang
Mar 21, 2009·The Laryngoscope·Jennifer GoyPatti A Groome
Apr 18, 2000·The Journal of Pathology·S WarnakulasuriyaJ Houghton
Jul 27, 2005·Journal of Cancer Research and Clinical Oncology·Panayiotis A KyzasNiki J Agnantis
Apr 14, 2000·Clinical Otolaryngology and Allied Sciences·J GreenmanN D Stafford
Feb 14, 2006·Head & Neck·Eben L Rosenthal, Lynn M Matrisian
Jun 29, 2011·Histopathology·Alan Roger Santos-SilvaMarcio Ajudarte Lopes
Aug 22, 2014·Journal of Microscopy·T Mattfeldt, F Fleischer
Sep 3, 2016·Oral Diseases·K-Y KimI-H Cha
Aug 14, 2018·Head & Neck·Narayana SubramaniamSubramania Iyer
Nov 27, 2018·The American Journal of Surgical Pathology·Melanie BoxbergWilko Weichert
Sep 24, 2019·Frontiers in Oncology·Wenli WuShengsheng Xu
Oct 19, 2000·The Laryngoscope·H VargasL T Galati
Sep 29, 1999·Genes, Chromosomes & Cancer·M KujawskiS Knuutila
Mar 27, 2003·Head & Neck·Signe FrieslandAnders Nilsson
Dec 25, 2008·Acta Oncologica·Mattias HedmanOla Brodin
Jun 2, 2004·Molecular Carcinogenesis·Eben RosenthalCandece Gladson
Feb 6, 2008·World Journal of Surgical Oncology·Gareth Morris-StiffTimothy J Havard
Jun 4, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Federico Maria GioacchiniMassimo Re
Sep 12, 2008·The New England Journal of Medicine·Robert I Haddad, Dong M Shin
Aug 16, 2000·Clinical Otolaryngology and Allied Sciences·J J HomerN D Stafford
Apr 16, 2005·Molecular Cancer Research : MCR·Eben L RosenthalGlenn E Peters
Jul 4, 2021·Clinical Oral Investigations·Wafa KhanShankargouda Patil
Jan 30, 2007·Oral Oncology·Jaana RautavaRisto-Pekka Happonen