Prognostic Value of Coronary CT Angiography With Selective PET Perfusion Imaging in Coronary Artery Disease

JACC. Cardiovascular Imaging
Teemu MaaniittyJuhani Knuuti

Abstract

The purpose of this study was to evaluate the prognostic value of sequential hybrid imaging strategy in which positron emission tomography (PET) perfusion imaging is performed selectively in patients with suspected obstructive coronary artery disease (CAD) on coronary computed tomography angiography (CTA). Coronary CTA is an accurate diagnostic test for excluding obstructive CAD. However, the positive predictive value is suboptimal. We investigated 864 consecutive symptomatic patients with intermediate probability of CAD who adhered to the sequential imaging approach. PET myocardial perfusion imaging using 15O-labeled water during adenosine stress was performed when suspected obstructive stenosis was present on coronary CTA. The major adverse events (AEs) including all-cause mortality, myocardial infarction (MI), and unstable angina pectoris (UAP) were recorded. During a median follow-up of 3.6 years, 16 deaths, 10 MIs, and 5 UAPs occurred. Obstructive CAD was excluded by coronary CTA in 462 (53%) patients who had significantly lower annual AE rate than did patients with suspected obstructive stenosis on coronary CTA (0.4% vs. 1.5%; p = 0.003). The latter underwent PET study, on which 195 (49%) had normal and 207 had abnormal p...Continue Reading

Citations

Feb 16, 2018·European Heart Journal Cardiovascular Imaging·Antti Saraste, Juhani Knuuti
Jan 3, 2019·European Heart Journal·Victoria DelgadoJeroen J Bax
Aug 2, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Antti Saraste, Juhani Knuuti
Sep 11, 2019·European Heart Journal·Juhani KnuutiUNKNOWN ESC Scientific Document Group
Oct 18, 2019·European Heart Journal Cardiovascular Imaging·Michiel J BomPaul Knaapen
Nov 9, 2019·European Heart Journal Cardiovascular Imaging·Danilo NegliaUNKNOWN EVINCI Study Investigators
Jul 28, 2020·Der Urologe. Ausg. A·D TeberK März
Apr 25, 2019·The International Journal of Cardiovascular Imaging·L NissenM Bøttcher
May 18, 2020·European Heart Journal Cardiovascular Imaging·Robert J H MillerDaniel S Berman
Nov 12, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Esa HarjulahtiAntti Saraste
Aug 9, 2020·JACC. Cardiovascular Imaging·Leslee ShawY Chandrashekhar
Nov 3, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Roberto SciagràUNKNOWN Cardiovascular Committee of the European Association of Nuclear Medicine (EANM)
Nov 30, 2020·JACC. Cardiovascular Imaging·Juhani Knuuti, Antti Saraste
Apr 9, 2021·International Journal of Cardiology·Jan Walter BenjaminsLuis Eduardo Juarez-Orozco
May 6, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Reetta SiekkinenJarmo Teuho
Jun 10, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Teemu MaaniittyAntti Saraste
May 11, 2021·Clinical Physiology and Functional Imaging·Wail NammasAntti Saraste

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