Prognostic value of CT myocardial perfusion imaging and CT-derived fractional flow reserve for major adverse cardiac events in patients with coronary artery disease

Journal of Cardiovascular Computed Tomography
M van AssenU Joseph Schoepf

Abstract

The purpose of this study was to analyze the prognostic value of dynamic CT perfusion imaging (CTP) and CT derived fractional flow reserve (CT-FFR) for major adverse cardiac events (MACE). 81 patients from 4 institutions underwent coronary computed tomography angiography (CCTA) with dynamic CTP imaging and CT-FFR analysis. Patients were followed-up at 6, 12, and 18 months after imaging. MACE were defined as cardiac death, nonfatal myocardial infarction, unstable angina requiring hospitalization, or revascularization. CT-FFR was computed for each major coronary artery using an artificial intelligence-based application. CTP studies were analyzed per vessel territory using an index myocardial blood flow, the ratio between territory and global MBF. The prognostic value of CCTA, CT-FFR, and CTP was investigated with a univariate and multivariate Cox proportional hazards regression model. 243 vessels in 81 patients were interrogated by CCTA with CT-FFR and 243 vessel territories (1296 segments) were evaluated with dynamic CTP imaging. Of the 81 patients, 25 (31%) experienced MACE during follow-up. In univariate analysis, a positive index-MBF resulted in the largest risk for MACE (HR 11.4) compared to CCTA (HR 2.6) and CT-FFR (HR 4.6)...Continue Reading

Citations

May 2, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Elona Rrapo Kaso, Jamieson M Bourque
Feb 7, 2020·Japanese Journal of Radiology·Yuki TanabePrabhakar Rajiah
Jul 6, 2020·The International Journal of Cardiovascular Imaging·Verena BrandtChristian Tesche
Jun 18, 2020·European Radiology Experimental·M van AssenR Vliegenthart
Oct 14, 2020·La Radiologia medica·Sara SeitunFilippo Cademartiri
Dec 9, 2020·Journal of Clinical Medicine·Francesca BaessatoGianluca Pontone
Jan 16, 2020·Radiology. Cardiothoracic Imaging·Jonathan R Weir-McCall, Timothy A Fairbairn

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