Prognostic value of cyclin D1, p27, and p63 in oral leukoplakia

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
György Kövesi, Béla Szende

Abstract

Studies on the expression of genes regulating cell proliferation and apoptosis are essential to help better understand the severity and possible malignant transformation of oral leukoplakia. The characteristics of cyclin D1, p27, and p63 were investigated in this microscopic study, complementing our previous results with Ki67, p53, and the apoptosis index. Clinical and histologic as well as immunohistochemical studies were carried out on oral leukoplakia of 18 patients. Homogenous, or non-homogenous (nodular or speckled) and erythroleukoplakia were determined clinically. Pathologic classification was performed according to the degree of dysplasia. Immunoperoxidase reaction for cyclin D1, p27, and p63 was carried out on the biopsy specimens and the positivity of the reactions was calculated for 1000 epithelial cells. The expression of cyclin D1 increased in parallel with the severity of leukoplakia. The p27 index was 14-16% in homogenous and nodular leukoplakias but it was substantially lower to 1-2% in erythroleukoplakia. The p63 index was 10% in homogenous, 5% in nodular or speckled, but nearly 20% in erythroleukoplakia, on the average. These results suggest that the characteristic expression of cyclin D1, p27, and p63 in vari...Continue Reading

References

Oct 1, 1978·Oral Surgery, Oral Medicine, and Oral Pathology·I R KramerL H Sobin
Jan 8, 1998·International Journal of Cancer. Journal International Du Cancer·R KyomotoM Fukumoto
Apr 4, 2000·Oral Oncology·S C Liu, A J Klein-Szanto
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·K HibiD Sidransky
Mar 16, 2001·Breast Cancer Research : BCR·R ChiarleG Inghirami
Apr 24, 2001·Journal of Cancer Research and Clinical Oncology·R MathewR Ralhan
Oct 16, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Giancarlo PruneriGiuseppe Viale
Dec 14, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Michael H WeinsteinMassimo Loda
Jan 22, 2003·Virchows Archiv : an International Journal of Pathology·Alfons Nadal, Antonio Cardesa
Feb 18, 2003·Molecular and Cellular Biology·J Alan DiehlAndrew Emili
Aug 23, 2003·Oncogene·Roseann MulloyRobert A Hipskind
Nov 25, 2003·Current Opinion in Otolaryngology & Head and Neck Surgery·Felicia L Johnson
Dec 3, 2003·Oncogene·Jeannette Philipp-StaheliChristopher J Kemp
Mar 9, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Yuk-Kwan ChenLi-Min Lin

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Citations

Feb 11, 2012·Medicina oral, patología oral y cirugía bucal·Daniela-Cotta RibeiroMaria-Cássia-Ferreira Aguiar
Jul 8, 2014·Oral Oncology·M A González-MolesC Scully
Feb 25, 2014·Expert Review of Anticancer Therapy·Aru PanwarAaron Wieland
Dec 19, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Joelma Sousa LimaSuzana C Orsini Machado de Sousa
Nov 12, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Gayani PitiyageSaman Warnakulasuriya
Jun 19, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Brunno Santos de Freitas SilvaDécio dos Santos Pinto Júnior
Jan 25, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Aladim Gomes LameiraDécio Dos Santos Pinto
Jun 19, 2013·Journal of Investigative and Clinical Dentistry·B R VarunElizabeth Joshua
Sep 13, 2007·IEEE Transactions on Pattern Analysis and Machine Intelligence·Ajmal S MianRobyn Owens
Feb 1, 2014·International Journal of Cancer. Journal International Du Cancer·Kalen R DionneSok Ching Cheong
Jan 9, 2014·Expert Review of Anticancer Therapy·Aru PanwarAaron Wieland
Sep 16, 2015·Applied Immunohistochemistry & Molecular Morphology : AIMM·Rosane Borges DiasClarissa Araújo Gurgel Rocha
Jun 3, 2021·Diagnostics·Maria GeorgakiNikolaos G Nikitakis

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