PMID: 9529014Apr 7, 1998Paper

Prognostic value of cyclin E and p53 expression in gastric carcinoma

Cancer
T SakaguchiH Nakano

Abstract

Cyclins and wild-type p53 are prime cell cycle regulators and may be involved in tumorigenesis. Cyclin E is a late G1 cyclin and its abnormalities have been reported in several cancers. The authors investigated the correlation between cyclin E expression and progression of gastric carcinoma. The expression of cyclin E and p53 proteins was investigated retrospectively in 116 patients with gastric carcinoma. Immunohistochemical staining of the paraffin sections was performed using monoclonal antibodies to cyclin E and p53. The total cyclin E positive rate was 44.0% (51 of 116) of all cases, 26 of which were strongly positive. Strong cyclin E expression frequently was observed in deeply invasive tumors, tumors with lymph node metastasis, and tumors of advanced stage. The incidence of p53 expression was higher in the cyclin E positive tumors than in the other tumors. With regard to prognosis, patients whose tumors had both strong positivity for cyclin E and positivity for p53 had significantly poorer prognosis. In multivariate analysis, the combined variable of cyclin E and p53 was an independent prognostic indicator together with serosal invasion and tumor size. These data suggest the cyclin E expression correlates with p53 expres...Continue Reading

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Citations

Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·J A EncinasT Kimura
Aug 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jennifer AurandtKun-Liang Guan
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