Prognostic value of different serum biomarkers for left ventricular remodelling after ST-elevation myocardial infarction treated with primary percutaneous coronary intervention

Heart
Jose Angel Urbano-MoralAngel Martinez

Abstract

Mortality derived from ST-elevation myocardial infarction (STEMI) has decreased due to primary percutaneous coronary intervention (PCI). Paradoxically, the incidence of heart failure secondary to left ventricular remodelling (LVR) is on the rise due to the survival derived from reperfusion strategies. The aim of this study was to assess the prognostic value for LVR of biomarkers involved in several pathophysiological mechanisms activated during STEMI treated with primary PCI. 112 patients with STEMI undergoing primary PCI were evaluated. LVR was defined as a ≥20% increase in the left ventricular end-diastolic volume at 6-month follow-up assessed using echocardiogram as compared with that at discharge. Blood samples were obtained for glucose, N-terminal pro-brain natriuretic peptide, troponin T (TnT), matrix metalloproteinase 9, procollagen type-I N-terminal propeptide and high-sensitivity C reactive protein (hs-CRP). 24 patients (21%) developed LVR. Higher levels of maximum TnT, and matrix metalloproteinase 9 and hs-CRP at discharge, were detected as independent risk factors for LVR (OR 1.310, p=0.03; OR 1001, p=0.04; OR 1.040, p=0.04, respectively). Both TnT and hs-CRP showed significant ability to distinguish patients who dev...Continue Reading

Citations

Jan 15, 2014·Critical Reviews in Clinical Laboratory Sciences·Giuseppe Lippi, Gianfranco Cervellin
Jul 18, 2015·Revista Española De Cardiología·Eva M Calderón-SánchezAntonio Ordóñez
Jun 28, 2016·International Journal of Cardiology·Martin ReindlBernhard Metzler
Feb 15, 2015·European Heart Journal. Acute Cardiovascular Care·Ignacio M SeropianAntonio Abbate
Apr 12, 2018·European Heart Journal. Acute Cardiovascular Care·Martin ReindlBernhard Metzler
Jul 4, 2020·BMC Cardiovascular Disorders·Damien LegalloisFarzin Beygui
Jun 11, 2021·Frontiers in Cardiovascular Medicine·Xiaoyuan ZhangBo Yu

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