Prognostic value of diffusion-weighted magnetic resonance imaging and 18F-fluorodeoxyglucose-positron emission tomography/computed tomography after concurrent chemoradiotherapy in uterine cervical cancer

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Jung Jae ParkByung Kwan Park

Abstract

To evaluate the prognostic value of diffusion-weighted imaging (DWI) and positron emission tomography/computed tomography (PET/CT) for predicting disease progression after concurrent chemoradiotherapy (CCRT) in cervical cancer. A total of 67 locally advanced cervical cancer patients who received CCRT underwent both DWI and PET/CT before and during (at 1month) treatment. The mean apparent diffusion coefficient (ADCmean) and maximum standardized uptake value (SUVmax) were measured on the tumor and the percentage changes between 2 time points (ΔADCmean and ΔSUVmax) were calculated. The ΔADCmean and ΔSUVmax were compared in terms of predicting disease progression after CCRT. During a mean follow-up of 2.7years, disease progression was identified in 16 patients (23.9%). The ΔADCmean and ΔSUVmax were significantly correlated (Spearman correlation coefficient, 0.38; P=0.002). For predicting disease progression, the integrated area under the curves of ΔADCmean (0.791) and ΔSUVmax (0.781) were not significantly different (P=0.88). On multivariate analysis, both ΔADCmean and ΔSUVmax were the independent predictors of disease progression (hazard ratio, 7.9 and 8.7; P, 0.001 and <0.001, respectively). The percentage changes of ADCmean and ...Continue Reading

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Citations

Oct 12, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yui WatanabeHajime Sakuma

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