Prognostic Value of Early Postoperative Troponin T in Patients Undergoing Coronary Artery Bypass Grafting

Journal of the American Heart Association
Brigitta GahlPeter Jüni

Abstract

Cardiac troponin T (cTnT) is elevated after coronary artery bypass grafting surgery. The aim of this study was to determine the association between cTnT elevations between 6 and 12 hours after coronary artery bypass grafting and in-hospital outcome. We prospectively studied 1722 patients undergoing isolated coronary artery bypass grafting. We assessed the association between conventional cTnT (749 patients) and high-sensitivity cTnT (hs-cTnT; 973 patients) 6 to 12 hours postoperatively with in-hospital major adverse cardiac or cerebrovascular events (MACCE), a composite of all-cause death, myocardial infarction, or stroke. The prespecified secondary outcome was a safety composite of MACCE, resuscitation, intensive care unit readmission or admission ≥48 hours, inotrope or vasopressor use ≥24 hours, or new-onset renal insufficiency. Among patients with a conventional cTnT measurement, 92 experienced a MACCE (12%) and 146 experienced a safety composite event (19%). Likewise, for hs-cTnT, 114 experienced a MACCE (12%) and 153 experienced a safety composite event (16%). Compared with cTnT ≤200 ng/L, each 200-ng/L increment in cTnT was associated with a monotonous increase in the odds of MACCE and the safety composite outcome. Conven...Continue Reading

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Citations

Apr 20, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Martin H KeppelJanne Cadamuro
Feb 26, 2019·Frontiers in Cardiovascular Medicine·Jun TanihataSusumu Minamisawa
Jun 25, 2021·International Journal of General Medicine·Yuying GuYangyang Zhang
Nov 12, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Filippo CreaRiccardo Rinaldi

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Methods Mentioned

BETA
coronary artery bypass
Biosensors

Software Mentioned

Stata
R

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