Prognostic value of endocapillary hypercellularity in IgA nephropathy patients with no immunosuppression

Journal of Nephrology
Aron ChakeraIan S D Roberts

Abstract

Interpretation of retrospective clinicopathological studies of IgA nephropathy (IgAN) has been confounded by immunosuppression bias. In published validation studies of the Oxford Classification of IgAN, an average of 33 % of patients received non-randomised steroid and/or cytotoxic therapy. In order to determine the true impact of proliferative lesions on the natural history of IgAN, analysis of patient cohorts that have received no immunosuppression is required. We performed a retrospective single centre study of patients with IgAN managed without immunosuppressive therapy. Biopsies were scored according to the Oxford Classification. The primary outcomes were renal survival or a rapid loss of renal function defined as a decline in eGFR of >5 ml/min/year. 237 patients with IgAN were identified with a mean follow-up of 82 months. 200 had biopsies available for review, of which 156 were adequate for scoring using the Oxford Classification. 9/156 patients (5.8 %) received some immunosuppressive therapy, mostly for unrelated conditions: these were excluded. In multivariate COX regression, including histological and clinical data, the only independent predictors of time to ESRD were baseline eGFR (HR 0.96 per ml/min increase, p = 0....Continue Reading

References

Jun 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M Haas
May 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ritsuko KatafuchiSatoru Fujimi
Jun 5, 2007·Bulletin of the World Health Organization·Tikki Pang
Jan 29, 2008·Seminars in Nephrology·François C BerthouxAïda Afiani
Jul 3, 2009·Kidney International·UNKNOWN Working Group of the International IgA Nephropathy Network and the Renal Pathology SocietyHong Zhang
Jul 3, 2009·Kidney International·UNKNOWN Working Group of the International IgA Nephropathy Network and the Renal Pathology SocietyHong Zhang
Jan 22, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Michael WalshBrenda Hemmelgarn
Jan 25, 2011·Journal of the American Society of Nephrology : JASN·François BerthouxLise Thibaudin
Feb 11, 2011·Arthritis Care & Research·Christine HsiehMarcus R Clark
May 6, 2011·Kidney International·Andrew M HerzenbergDaniel C Cattran
Aug 20, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Su-Fang ShiHai-Yan Wang
Mar 21, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Qiong WuMasafumi Fukagawa
Apr 14, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sean J Barbour, Heather N Reich
Jan 25, 2013·Kidney International·Tanvir C TurinBrenda R Hemmelgarn
Mar 23, 2013·Current Opinion in Nephrology and Hypertension·Ian S D Roberts
Apr 4, 2014·Kidney International·Rosanna CoppoUNKNOWN VALIGA study of the ERA-EDTA Immunonephrology Working Group

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Citations

Feb 22, 2017·Current Opinion in Nephrology and Hypertension·Maria F Soares, Ian S D Roberts
Feb 13, 2018·Current Opinion in Nephrology and Hypertension·Sean Barbour, Heather Reich
Nov 27, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rosanna Coppo
Oct 5, 2019·Journal of Clinical Medicine·Bogdan ObrișcăGabriel Mircescu
Nov 23, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hernán Trimarchi, Rosanna Coppo
Aug 25, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Izabella Z A PawluczykJonathan Barratt
Nov 21, 2018·BMC Nephrology·Judith Isabel SchimpfThomas Rauen
Sep 19, 2020·International Urology and Nephrology·Dongmei WenWei Qin
Apr 10, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hannah BeckwithTom Cairns
Oct 11, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Shigeru TanakaKazuhiko Tsuruya
Feb 16, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rosanna Coppo
Aug 11, 2020·Kidney Research and Clinical Practice·Ji-Hye LeeSamel Park
Feb 18, 2021·Clinical and Experimental Nephrology·Chisako KamanoUNKNOWN Japan IgA nephropathy prospective cohort Study Group
Apr 28, 2021·International Urology and Nephrology·Xinyao LuoYahong Hu
May 18, 2021·Indian Journal of Nephrology·Neha Agrawal, Swarnalata Gowrishankar
Nov 18, 2021·Journal of Nephrology·Yasar CaliskanHalil Yazici

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