Prognostic value of fasting glucose on the risk of heart failure and left ventricular systolic dysfunction in non-diabetic patients with ST-segment elevation myocardial infarction.

Frontiers of Medicine
Hui WangS Zhang

Abstract

Recent studies have shown that acute blood glucose elevation in patients with ST-segment elevation myocardial infarction (STEMI) suggests a poor prognosis. To investigate the effect of fasting blood glucose (FBG) on the risk of heart failure (HF) and left ventricular systolic dysfunction (LVSD) in non-diabetic patients undergoing primary percutaneous coronary intervention (PCI) for acute STEMI, we retrospectively recruited consecutive non-diabetic patients who underwent primary PCI for STEMI in our hospital from February 2003 to March 2015. The patients were divided into two groups according to the FBG level. A total of 623 patients were recruited with an age of 61.3 ± 12.9 years, of whom 514 (82.5%) were male. The HF risk (odds ratio 3.401, 95% confidence interval (CI) 2.144-5.395, P < 0.001) was significantly increased in patients with elevated FBG than those with normal FBG. Elevated FBG was also independently related to LVSD (β 1.513, 95%CI 1.282-1.785, P < 0.001) in a multiple logistics regression analysis. In conclusion, elevated FBG was independently associated with 30-day HF and LVSD risk in non-diabetic patients undergoing primary PCI for STEMI.

References

Oct 23, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J R KerstenD C Warltier
Nov 3, 2004·Journal of the American College of Cardiology·Giancarlo MarenziAntonio L Bartorelli
Apr 12, 2008·Journal of the American College of Cardiology·Peter A McCullough
Jan 3, 2009·Journal of the American College of Cardiology·Justin A EzekowitzFinlay A McAlister
Apr 18, 2009·Journal of the American College of Cardiology·Raffaele MarfellaGiuseppe Paolisso
Sep 8, 2009·The American Journal of Cardiology·Masaharu IshiharaUNKNOWN Japanese Acute Coronary Syndrome Study (JACSS) Investigators
Apr 3, 2010·Journal of the American College of Cardiology·Joshua M StolkerMikhail Kosiborod
Jul 8, 2011·Angiology·Shi-Wei YangUNKNOWN Beijing Elderly Acute Myocardial Infarction Study (BEAMIS) Group
Aug 21, 2013·Journal of the American College of Cardiology·Dimitris TousoulisChristodoulos Stefanadis
Mar 13, 2014·European Journal of Preventive Cardiology·Jacek KowalczykZbigniew Kalarus
Dec 3, 2014·The American Journal of Cardiology·Masashi FujinoHisao Ogawa
Aug 10, 2016·Lancet·Grant W ReedChristopher P Cannon
Dec 3, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Kazuyuki YahagiRenu Virmani
Jan 28, 2017·International Journal of Cardiology·Eun Jung KimUNKNOWN KAMIR-NIH registry investigators

❮ Previous
Next ❯

Citations

Aug 19, 2021·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Ramin EskandariYousef Rezaei

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.