Prognostic Value of Gamma-Glutamyltransferase in Male Patients With Idiopathic Pulmonary Arterial Hypertension

Frontiers in Cardiovascular Medicine
Gang-Hua LuRui Zhang

Abstract

Background: The elevated gamma-glutamyltransferase (GGT) activity is regarded as an indicator of cardiovascular disease, with males having higher values than females. The greater incidence of idiopathic pulmonary arterial hypertension (IPAH) is observed in women, whereas prognosis is poor in men. The present study aims to investigate the potential association of GGT on male patients. Methods: Serum GGT levels were measured in 338 consecutive adult IPAH patients, who underwent bone morphogenetic protein receptor type 2 (BMPR2) genetic counseling, and matched with healthy subjects by sex and age. The followed interval was 48 ± 34 months. Results: Increased serum GGT levels were more common in patients with IPAH than controls (p < 0.001). GGT values were significantly higher in male patients than those of females (p < 0.001). Compared with female patients with BMPR2 mutation, GGT level in male patients with BMPR2 mutation was further increased (p = 0.002). Higher GGT levels were associated with worse hemodynamics and Nterminal pro B-type natriuretic peptide in all patients. However, males with a GGT concentration ≥ 53 U/L had a worse survival than those of females. Contrarily, if GGT concentration <53 U/L, there was no survival di...Continue Reading

References

Sep 21, 2001·Critical Reviews in Clinical Laboratory Sciences·J B Whitfield
Jan 14, 2003·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN American College of Chest Physicians
Apr 11, 2003·Diabetologia·D-H LeeD R Jacobs
Sep 28, 2005·Circulation·Elfriede RuttmannUNKNOWN Vorarlberg Health Monitoring and Promotion Program Study Group
Oct 13, 2006·Atherosclerosis·Atsushi HozawaUNKNOWN NIPPON DATA90 Research Group
Nov 11, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Douglas S LeeRamachandran S Vasan
Oct 11, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Josiane SteinmetzUNKNOWN Periodic Health Examination Centers Laboratory Working Group
Jul 12, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Alexander M StrasakUNKNOWN Vorarlberg Health Monitoring and Promotion Program Study Group
Aug 12, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robin HaringHenry Völzke
Jun 28, 2011·American Journal of Respiratory and Critical Care Medicine·Soban UmarMansoureh Eghbali
Feb 22, 2012·Biology of Sex Differences·Eric D AustinKirk B Lane
Mar 6, 2012·The American Journal of Emergency Medicine·Ali ZorluMehmet Birhan Yilmaz
Aug 28, 2012·Circulation. Cardiovascular Genetics·Dong LiuZhi-Cheng Jing
Jun 8, 2013·American Journal of Respiratory Cell and Molecular Biology·Joshua P FesselJames D West
Sep 12, 2013·Redox Biology·Francesco BellantiGaetano Serviddio
Jul 4, 2015·Annals of Clinical Biochemistry·Sudha Bulusu, Manisha Sharma
Feb 13, 2016·Heart·Catherine M Otto
Feb 16, 2016·Journal of Atherosclerosis and Thrombosis·Yuanying LiUNKNOWN EPOCH-JAPAN Research Group
Aug 12, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Setor K Kunutsor
Nov 11, 2016·Current Hypertension Reports·Andrew Foderaro, Corey E Ventetuolo
Mar 11, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Arthur P ArnoldKathryn Sandberg
Jul 28, 2018·Advances in Experimental Medicine and Biology·Craig K DochertyMargaret R MacLean
Dec 14, 2018·The European Respiratory Journal·Gérald SimonneauRogerio Souza
Dec 28, 2019·International Journal of Molecular Sciences·Stevan P Tofovic, Edwin K Jackson

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