Prognostic value of gasometric parameters of carbon dioxide in resuscitation of septic patients. A bibliography review

Revista española de anestesiología y reanimación
J Á Lamsfus-PrietoG Marcano-Rodriguez

Abstract

The anaerobic metabolism is the cornerstone in physiopathology of septic shock. Nowadays we have both the central or mixed venous oxygen saturation and lactate levels to monitoring the metabolism in septic patients. Some studies have shown that normalization of systemic hemodynamic and oxygen metabolism variables not prevent progression to multiorgan damage and death. Recently has been proposed the venous-to-arterial carbon dioxide difference (ΔpvaCO2) as an alternative marker of tissue hypoperfusion, like Cardiac Index. High ΔpvaCO2 predicts adverse outcomes. Also has been proposed both, the ratio between the ΔpvaCO2 and arterial-to-venous oxygen content difference (ΔCavO2): ΔpvaCO2/ΔCavO2; and, the ratio between venous-to-arterial carbon dioxide difference (ΔCvaCO2) and ΔCavO2: ΔCvaCO2/ΔCavO2, as markers of anaerobic metabolism. Both of high ratios are related to high levels of lactate and worse prognosis. Therefore in patients with sepsis the combination of markers of resuscitation could be important to improve the outcomes.

References

Jun 1, 1990·Critical Care Medicine·C E MecherM H Weil
Mar 1, 1995·European Journal of Clinical Investigation·L Lind
Jan 17, 2002·The New England Journal of Medicine·E RiversUNKNOWN Early Goal-Directed Therapy Collaborative Group
Mar 29, 2003·Intensive Care Medicine·Mitchell M LevyUNKNOWN International Sepsis Definitions Conference
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Dec 17, 2010·Croatian Medical Journal·Rosana TroskotInes Mrakovčić-Šutić
Jan 7, 2011·Journal of Clinical Epidemiology·Howard BalshemGordon H Guyatt
Jan 31, 2013·Intensive Care Medicine·R P DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
Apr 6, 2013·Intensive Care Medicine·Paul A van BeestE Christiaan Boerma
Oct 2, 2013·Mayo Clinic Proceedings·Lars W AndersenMichael W Donnino
Dec 18, 2013·Critical Care : the Official Journal of the Critical Care Forum·Gustavo A Ospina-TascónGlenn Hernández
Oct 2, 2014·The New England Journal of Medicine·Sandra L PeakePatricia Williams
Mar 18, 2015·The New England Journal of Medicine·Paul R MounceyUNKNOWN ProMISe Trial Investigators

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Citations

Aug 19, 2021·Brazilian Journal of Anesthesiology·Juan P BouchacourtJuan A Riva

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