PMID: 16523815Mar 10, 2006Paper

Prognostic value of haemoglobin levels during concurrent radio-chemotherapy in the treatment of oesophageal cancer

Clinical Oncology : a Journal of the Royal College of Radiologists
Dirk RadesWinfried Alberti

Abstract

To evaluate the prognostic value of haemoglobin levels during radio-chemotherapy for overall survival, metastases-free survival (MFS) and locoregional control in patients with locally advanced oesophageal cancer. Age, gender, performance status, tumour location, tumour length, histology, histologic grading, T-stage, N-stage, UICC-stage and weekly haemoglobin levels during concurrent radio-chemotherapy were retrospectively investigated and related to outcome in 108 patients, who received radio-chemotherapy for stage II/III oesophageal cancer. Radio-chemotherapy consisted of 59.4-60 Gy irradiation, two to four courses of cisplatin (75 mg/m2 on day 1) and 5-fluorouracil (1000 mg/m2 on days 1-5). Haemoglobin levels during radio-chemotherapy were compared among the following three groups: patients with over 60% of haemoglobin levels less than 12 g/dl; patients with over 60% of haemoglobin levels at 12-14 g/dl; and patients with over 60% of haemoglobin levels greater than 14 g/dl. On univariate analysis, haemoglobin levels of 12-14 g/dl and greater than 14 g/dl during concurrent radio-chemotherapy provided better outcomes than haemoglobin levels less than 12 g/dl. The 2-year overall survival rates were 34%, 35% and 16%, respectively ...Continue Reading

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Citations

Feb 24, 2009·International Journal of Radiation Oncology, Biology, Physics·Hee Chul ParkSunil Krishnan
Sep 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Seye Kazem MirinezhadBehnam Nasiri
Jul 12, 2007·Nature Clinical Practice. Oncology·Dirk Rades, Steven E Schild

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