Prognostic value of hemostasis-related parameters for prediction of organ dysfunction and mortality in sepsis

Turkish Journal of Medical Sciences
Dunja MihajlovicSnezana Brkic

Abstract

Clinical manifestations of sepsis are not caused directly by the invading pathogens, but rather mostly by systemic inflammation that leads to activation of the coagulation system. The aim of this study was to determine whether levels of hemostasis- related parameters measured in intensive care unit admissions are associated with mortality and severity in patients with sepsis. Eighty-five patients who fulfilled criteria for a diagnosis of sepsis were included in our study. Platelet count, activated partial thromboplastin time (aPTT), prothrombin time (PT), thrombin time, D-dimer, and fibrinogen levels were determined within the first 24 h from sepsis onset. Differences between groups of septic patients were assessed by Mann-Whitney U test and Kruskal-Wallis test. Logistic regression analysis was performed to test the joint effect of different predictors. Prolonged aPTT and PT with higher D-dimer concentrations in patients with sepsis are associated with more severe forms of the disease, aPTT was prolonged in nonsurvivors, while platelet count and fibrinogen levels were higher in survivors. Platelet count and aPTT ratio are independent predictors of fatal outcome in our logistic regression model. Hemostasis-related parameters hav...Continue Reading

Citations

Feb 7, 2017·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Dunja MihajlovicGorana Mitic
Nov 18, 2018·Annals of Intensive Care·Christian NiederwangerPetra Innerhofer
Dec 30, 2016·Journal of Veterinary Internal Medicine·S J ViitanenM M Rajamäki
Jan 4, 2020·Acta Anaesthesiologica Scandinavica·Sigurdur BenediktssonThomas Kander
Aug 17, 2021·Intensive Care Medicine Experimental·O SommerfeldF Bloos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Acta Medica Croatica : C̆asopis Hravatske Akademije Medicinskih Znanosti
Dagmar OberhoferKresimir Cala
Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Dunja MihajlovicSnezana Brkic
Annals of Laboratory Medicine
Jung-Ah KimHyun Kyung Kim
© 2021 Meta ULC. All rights reserved