Prognostic value of HMGA2, CDK4, and JUN amplification in well-differentiated and dedifferentiated liposarcomas

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Esma Saâda-BouzidLaurence Bianchini

Abstract

HMGA2, CDK4, and JUN genes have been described as frequently coamplified with MDM2 in atypical lipomatous tumor, well-differentiated liposarcoma, and dedifferentiated liposarcoma. We studied the frequency of amplification of these genes in a series of 48 dedifferentiated liposarcomas and 68 atypical lipomatous tumors/well-differentiated liposarcomas. We correlated their amplification status with clinicopathological features and outcomes. Histologically, both CDK4 (P=0.007) and JUN (P=0.005) amplifications were associated with dedifferentiated liposarcoma, whereas amplification of the proximal parts of HMGA2 (5'-untranslated region (UTR) and exons 1-3) was associated with atypical lipomatous tumor/well-differentiated liposarcoma (P=0.01). CDK4 amplification was associated with axial tumors. Amplification of 5'-UTR and exons 1-3 of HMGA2 was associated with primary status and grade 1. Shorter overall survival was correlated with: age >64 years (P=0.03), chemotherapy used in first intent (P<0.001), no surgery (P=0.003), grade 3 (P<0.001), distant metastasis (P<0.001), node involvement (P=0.006), and CDK4 amplification (P=0.07). In multivariate analysis, distant metastasis (HR=8.8) and grade 3 (HR=18.2) were associated with shorter...Continue Reading

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Citations

Dec 14, 2019·Nature Communications·Makoto HirataKoichi Matsuda
Nov 14, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jose G MantillaBenjamin L Hoch
Dec 21, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·May P ChanPaul W Harms
Jan 28, 2021·International Journal of Molecular Sciences·Emi MashimaMotonobu Nakamura
Oct 29, 2020·Clinical Orthopaedics and Related Research·Eiji NakataToshifumi Ozaki
Apr 12, 2020·Cancer Treatment Reviews·Robert TylerAndrew Beggs
Apr 4, 2021·Diagnostics·Raf Sciot
Jul 1, 2021·Signal Transduction and Targeted Therapy·Victoria DamerellSharon Prince
Aug 10, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Fan TangXia-Wei Wei
Mar 19, 2021·Applied Immunohistochemistry & Molecular Morphology : AIMM·Jianming PeiShuanzeng Wei

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