[Prognostic value of immunohistochemistry in salivary gland cancer].

HNO
T EttlO Driemel

Abstract

The diversity of salivary gland malignancies as to morphology and clinical course makes it difficult to establish prognostic factors. The aim of this study was to evaluate the prognostic significance of, a. o., immunohistochemical criteria in a retrospective study of salivary gland cancer. Clinical and histologic data were recorded for 101 patients with carcinomas of the salivary glands. Immunohistochemistry was performed for Ki-67, P53, C-KIT, HER2, EGFR, and maspin. Correlations to disease-specific long-term survival (mean follow-up 4.7 years) were followed by univariate and multivariate analysis. Findings included the following: an association between loss of maspin and the presence of nodal metastasis, residual tumour, and poor overall survival for adenoid cystic carcinoma; common C-KIT expression in adenoid cystic carcinoma (92%); correlation of loss of C-KIT with high malignancy grade, nodal metastases, high proliferative activity (Ki-67>30%), and unfavourable survival in all tumours; common HER2 expression (83%) in salivary duct carcinoma but no relation to the total collective's survival. Overexpression of EGFR was associated with poor survival rates. In multivariate analysis, a high proliferation index was the stronges...Continue Reading

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Citations

Jul 31, 2012·Oral and Maxillofacial Surgery·Tobias EttlTorsten E Reichert
Jun 15, 2011·Pathology·Till Sebastian ClauditzWaldemar Wilczak
Dec 15, 2015·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Tobias AchTobias Ettl
Nov 18, 2008·Hematology/oncology Clinics of North America·Ranee Mehra, Roger B Cohen
Nov 28, 2008·Virchows Archiv : an International Journal of Pathology·Fumio IdeKaoru Kusama
Aug 8, 2015·Clinical Oral Investigations·T SchneiderU D A Müller-Richter

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