Prognostic value of in vitro sperm penetration into hormonally standardized human cervical mucus

Fertility and Sterility
W Eggert-KruseB Runnebaum


To analyze the prognostic value of the sperm cervical mucus penetration test (SCMPT), fresh semen samples of 99 male patients under infertility investigation were exposed to capillary tubes filled with freshly obtained cervical mucus (CM) of the patients' wives (WCM), fertile donors (DCM), and bovine CM (BCM). The quality of the human CM was standardized by oral administration of estrogens. The overall pregnancy rate after 6 months was 17.2% (17/99), and was significantly different in couples with poor and good SCMPT with WCM (1/44, 2.3% versus 16/55, 29%; P less than 0.001) in a prospective study. Human CM was superior to BCM as a penetration medium in providing more information about sperm function. The results suggest that in vitro sperm penetration testing with hormonally standardized CM of female partners adds an important dimension to sperm analysis with regard to fertility prognosis.


Feb 1, 2002·Fertility and Sterility·Waltraud Eggert-KruseThomas Strowitzki
Feb 24, 2000·Fertility and Sterility·W Eggert-KruseD Petzoldt
Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·M G Hull, D J Cahill
Jul 22, 2011·Science Translational Medicine·Theodore L TollnerGary N Cherr
Feb 8, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Andrea Bonisoli-AlquatiTimothy A Mousseau
Feb 5, 2008·Fertility and Sterility·Waltraud Eggert-KruseJörg R Schlehofer
Jun 12, 2012·Contraception·Rachel StewardDaniel R Mishell
Aug 1, 1990·International Journal of Andrology·W Eggert-KruseB Runnebaum
Mar 1, 2002·Human Reproduction·Waltraud Eggert-KruseThomas Strowitzki
Jul 21, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Sheena E M Lewis
Feb 10, 2006·International Journal of Andrology·R J Aitken
Jul 29, 2008·Human Reproduction·Theodore L TollnerGary N Cherr
Mar 3, 2001·Human Reproduction·W Eggert-KruseT Strowitzki
Jul 1, 1992·Andrologia·I GerhardB Runnebaum
Feb 20, 2018·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Leo HanJeffrey T Jensen
Apr 19, 2017·Molecular Reproduction and Development·Melissa A MoodyG Charles Ostermeier
Sep 1, 1994·Andrologia·F R OchsendorfR Milbradt
Jun 1, 2002·Journal of Pharmaceutical and Biomedical Analysis·Ulrike SahrbacherHans Robert Kalbitzer
Jun 15, 2021·The American Journal of Pathology·Bryce D WarrenMargaret G Petroff

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