Prognostic value of iodine-123 labelled BMIPP fatty acid analogue imaging in patients with myocardial infarction

European Journal of Nuclear Medicine
Nagara TamakiJ Konishi

Abstract

This study was undertaken to evaluate the prognostic value of iodine-123 labelled 15-iodophenyl-3-R,S-methyl pentadecanoic acid (BMIPP) imaging in patients with myocardial infarction. BMIPP is an iodinated methyl branched fatty acid analogue which is trapped in the myocardium with little washout, thereby reflecting fatty acid utilization in the myocardium. We previously reported that in patients with myocardial infarction, regions are often observed where reduced BMIPP uptake is seen relative to thallium-201 perfusion at rest. However, the clinical significance of such discordant BMIPP uptake remains unknown. Fifty consecutive patients with chronic myocardial infarction referred for stress thallium scan and coronary arteriography underwent BMIPP imaging at rest. Each patient was in a stable condition at the time of the radionuclide study. Follow-up was performed at a mean interval of 23 months to investigate the prognostic implications of the radionuclide studies. Nine patients had cardiac events during the follow-up period. Univariate analysis showed that the number of discordant BMIPP versus 201TL uptake segments was the best predictor of future cardiac events (P=0.0245), followed by the presence of discordant BMIPP uptake (P...Continue Reading

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Citations

Sep 8, 1997·European Journal of Nuclear Medicine·L H Opie, B Hesse
May 1, 1997·Annals of Nuclear Medicine·N TamakiJ Konishi
Dec 8, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Takayuki MatsukiKazuaki Shimamoto
May 5, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Junichi Taki, Ichiro Matsunari
Oct 24, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Yoichi Inaba, Steven R Bergmann
Nov 18, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Nagara Tamaki, Keiichiro Yoshinaga
Apr 7, 2005·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Nagara Tamaki
Feb 6, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Taishiro ChikamoriTsunehiko Nishimura
Jun 30, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Nagara TamakiYuko Kawai
May 20, 1998·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·E G DePueyN Tamaki
Jul 18, 2006·International Journal of Cardiology·Yoshihiro J AkashiStefan D Anker
Jun 5, 2008·Journal of cardiology·Yasuto UchidaJunichi Yamazaki

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