Prognostic value of keratin subtyping in transitional cell carcinoma of the upper urinary tract

Virchows Archiv : an International Journal of Pathology
C LangnerR Zigeuner

Abstract

To investigate the prognostic value of keratin subtyping in invasive transitional cell carcinomas (TCCs), we performed a systematic study applying 15 different monoclonal keratin antibodies on 53 upper urinary tract TCCs using a tissue microarray technique. Immunoreactivity was correlated with pT stages and tumour grades using the Fisher's exact test. Impact on disease-free survival was analysed using the Kaplan-Meier method and compared by the log-rank test. Immunoreactivity for keratins 5/6, 6, 7, 8, 13, 14, 17, 18, 19, 20, low molecular weight (LMW) keratins (8, 18) and high molecular weight (HMW) keratins (1, 5, 10, 14) was detected in varying quantities. Regarding semi-quantitative assessment, a prognostic impact was found for keratins 5/6, 7, 8, 13, 17, 20 and HMW keratins, with reduced expression or loss of immunoreactivity being significantly associated with disease progression. With respect to analysis of staining patterns, the retention of a basally accentuated labelling for keratin 5/6 and HMW keratin as well as a superficially accentuated labelling for keratin 20 was significantly associated with a favourable outcome. In conclusion, this investigation is the first to demonstrate a possible prognostic value for kerat...Continue Reading

References

Jan 1, 1993·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·V I GuelsteinS M Troyanovsky
Mar 28, 1998·Journal of Clinical Pathology·P Harnden, J Southgate
Jul 14, 1998·Nature Medicine·J KononenO P Kallioniemi
Sep 28, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·P ChuL M Weiss
Jun 8, 2001·American Journal of Clinical Pathology·S C LeeJ R Eshleman
Jan 18, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Peiguo G Chu, Lawrence M Weiss
May 16, 2002·Histopathology·P G Chu, L M Weiss
Dec 6, 2002·The American Journal of Pathology·Matt van de RijnPat Brown
Mar 5, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Mi-Kyung Kim, Seonwoo Kim
Apr 26, 2003·Virchows Archiv : an International Journal of Pathology·Burkhard HelpapMichael J Droller
Oct 23, 2003·American Journal of Clinical Pathology·Elizabeth M Genega, Christopher R Porter
Jan 17, 2004·Virchows Archiv : an International Journal of Pathology·Cord LangnerRichard Zigeuner

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Citations

Sep 6, 2006·Acta Biochimica Et Biophysica Sinica·Yu-Cong YangWei Chen
Sep 25, 2021·Virchows Archiv : an International Journal of Pathology·Cosima VölkelAnne Menz

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