PMID: 11908872Mar 23, 2002Paper

Prognostic value of Ki-67 (MIB-1) and p53 in ependymomas

Brain Tumor Pathology
S SuzukiK Fujii

Abstract

To determine whether Ki-67 (MIB-1) and p53 have prognostic value in ependymomas, clinicopathologic study was undertaken in 29 patients with this tumor. The clinical course correlated well with the histological grade according to the World Health Organization (WHO) grading system, and it was the worst in patients with anaplastic ependymoma. The percent expression of MIB-1 and p53 correlated with the histological grade of malignancy. With regard to the subtypes of benign ependymoma, the clinical course was the worst in clear-cell ependymoma, which had a significantly higher expression of MIB-1 and p53 than the other subtypes. Tanycytic ependymoma showed the most benign clinical course and the lowest expression of MIB-1 and p53. Although the WHO grading generally tended to correlate with the clinical course of ependymomas, these two subtypes--clear-cell ependymoma and tanycytic ependymoma--exhibited biological properties different from those of other grade II ependymomas.

References

Mar 1, 1978·Journal of Neuropathology and Experimental Neurology·R L Friede, A Pollak
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A K MetzgerP H Cogen
Aug 1, 1991·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·D SchifferA Tribolo
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·N KawanoS Yagishita
Jan 1, 1983·Acta Neuropathologica·N KawanoS Yagishita
Oct 1, 1993·The American Journal of Surgical Pathology·I SalmonR Kiss
Feb 1, 1996·Journal of Neuro-oncology·K L FinkP D Nisen
Jan 1, 1995·Acta neurochirurgica·T TominagaT Yoshimoto
Mar 1, 1997·Ultrastructural Pathology·L A Langford, G M Barré
Jul 1, 1997·The American Journal of Surgical Pathology·K W Min, B W Scheithauer
Jan 1, 1997·Acta neurochirurgica·M TakanoS Yagishita
Feb 25, 1998·British Journal of Neurosurgery·R I ErnestusN Klug
Jan 5, 1999·Journal of Neuro-oncology·A M RitterL A Langford
Feb 9, 2000·Acta Neuropathologica·S HayashiH Takahashi
Feb 10, 2000·Minimally Invasive Neurosurgery : MIN·M DaneyemezE Timuckaynak
Mar 11, 2000·Paediatric Anaesthesia·H HepağuşlarT Balcioğlu

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Citations

Feb 6, 2004·Brain Tumor Pathology·Atsuhiro KojimaYoichi Nakazato
Nov 27, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Murat KutlayUfuk Berber
Oct 27, 2009·Brain Tumor Pathology·Masayuki Shintaku, Takeshi Sakamoto
Jun 30, 2004·The American Journal of Surgical Pathology·Stefan WolfsbergerJohannes Hainfellner
Mar 4, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Sheng ZhangYupeng Chen
Feb 6, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Deepali JainVaishali Suri
Aug 30, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Mehar C SharmaVeer S Mehta
Aug 15, 2008·Neuro-oncology·Lee RidleyUNKNOWN Children's Cancer and Leukaemia Group Biological Studies Committee
Apr 24, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·G TamburriniC Di Rocco
May 13, 2008·Cancer·Philippe MetellusUNKNOWN Club de Neuro-Oncologie de la Société Française de Neurochirurgie and the Association des Neuro-Oncologues d'Expression Fran
Aug 2, 2006·Cytopathology : Official Journal of the British Society for Clinical Cytology·D TamiolakisC Simopoulos
Nov 3, 2004·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Amanda L RichardsCatriona Mc Lean
Mar 10, 2018·Journal of Neurosurgery. Spine·Maria WostrackJulia Onken
Aug 30, 2008·Advances in Anatomic Pathology·Dimitri TrembathArie Perry
Dec 21, 2007·Brain Tumor Pathology·Tamio ItoKazuo Nagashima
Feb 4, 2005·Journal of Neuro-oncology·Brian T RagelWilliam T Couldwell
Oct 28, 2015·Journal of Child Neurology·Nicholas A Vitanza, Sonia Partap
Jun 18, 2009·Molecular Cancer Research : MCR·John-Paul KildayRichard Grundy

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