Prognostic value of left ventricular apical tissue removed for HeartMate II left ventricular assist device placement

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Karl A SoderlundMarc K Halushka

Abstract

With the increasing use of left ventricular assist devices, the left ventricular apical core has become a more frequently encountered surgical pathology tissue. We investigated the prognostic value of this cardiac tissue in short-term patient mortality. Previous studies have shown that the degree of cardiac fibrosis correlates with improvements in ejection fraction and the likelihood of weaning from an assist device. Left ventricular apical core tissues from 29 sequential subjects who received a HeartMate II continuous axial flow left ventricular assist device were studied retrospectively to determine whether interstitial fibrosis, replacement fibrosis (scar), the presence of mural thrombus, or other histopathologic findings were associated with hemodynamic changes or mortality in this population. Patients received left ventricular assist devices as bridges to transplantation or as destination therapy. Interstitial fibrosis was determined by observer scoring and digital scoring methods. Before and after left ventricular assist device procedure, right heart catheterizations were reviewed for clinical cardiac data. The presence of replacement fibrosis in the apical core tissue significantly correlated with decreased improvement i...Continue Reading

References

Oct 1, 1993·Journal of the American College of Cardiology·K K HoD Levy
May 12, 1998·The Journal of Thoracic and Cardiovascular Surgery·P M McCarthyJ B Young
Oct 25, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·J D HosenpudR J Novick
Jan 22, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Brian A BrucknerKeith Youker
Apr 30, 2004·The Journal of Thoracic and Cardiovascular Surgery·Jeffrey A MorganYoshifumi Naka
Sep 13, 2005·The Journal of Thoracic and Cardiovascular Surgery·Goro MatsumiyaHikaru Matsuda
Nov 22, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jonathan E E YagerG Michael Felker
Nov 3, 2006·The New England Journal of Medicine·Emma J BirksMagdi H Yacoub
May 30, 2007·The Journal of Thoracic and Cardiovascular Surgery·Mark S SlaughterUNKNOWN IVAD Study Group
Sep 1, 2007·The New England Journal of Medicine·Leslie W MillerUNKNOWN HeartMate II Clinical Investigators

❮ Previous
Next ❯

Citations

Dec 3, 2014·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·James R Stone
Dec 4, 2014·Journal of the American Heart Association·Tatiana N SidorovaKatherine T Murray
Jul 5, 2016·Expert Review of Medical Devices·Hirohisa IkegamiYoshifumi Naka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.

Related Papers

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Aurélie CazesPatrick Bruneval
Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
A Bernard CollinsJames R Stone
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Brian A BrucknerKeith Youker
The New England Journal of Medicine
Leslie W MillerHeartMate II Clinical Investigators
© 2022 Meta ULC. All rights reserved