Abstract
To assess the prognostic value of the lymph node ratio (LNR) in patients with stage IIIC epithelial ovarian cancer (EOC) with node-positive in a Surveillance, Epidemiology, and End Results (SEER) population-based study.Data of patients were obtained from the SEER database from 1990 to 2012, and analyzed using Kaplan-Meier survival methods and Cox regression proportional hazard model. The prognostic value of the LNR on cause-specific survival (CSS) and overall survival (OS) were calculated. A total of 5,926 patients were identified. Univariate analysis showed that the number of removed lymph nodes (RLNs), the number of positive lymph nodes, and the LNR were significantly associated with CSS and OS (P < 0.05 for all). Multivariate analysis indicated that a higher LNR was an independent prognostic factor for poorer CSS (hazard ratio [HR]: 1.896, 95% confidence interval [CI]: 1.709-2.104, P < 0.001) and OS (HR:1.679, 95% CI: 1.454-1.939, P < 0.001). Among patients with LNR ≤ 0.42 and those with LNR > 0.42, the 5-year CSS was 53.1% and 34.7%, respectively (P < 0.001), and the 5-year OS was 50.4% and 32.0%, respectively (P < 0.001). The prognostic value of the LNR persisted for patients after stratification by the numbers of RLNs, tu...Continue Reading
References
Jan 30, 2002·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael Thun
Apr 21, 2005·Journal of the National Cancer Institute·Pierluigi Benedetti PaniciCostantino Mangioni
Aug 23, 2005·Gynecologic Oncology·Nobuhiro TakeshimaKatsuhiko Hasumi
May 24, 2007·British Journal of Cancer·J K ChanD S Kapp
Nov 6, 2007·Journal of Surgical Oncology·John K ChanDaniel S Kapp
Oct 28, 2008·Acta Obstetricia Et Gynecologica Scandinavica·Hee Seung KimSoon Beom Kang
Jan 24, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vincent Vinh-HungChristine Bouchardy
Mar 24, 2009·Archives of Gynecology and Obstetrics·Ali YavuzcanBurcu Cetinkaya
Mar 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andreas du BoisUNKNOWN Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens
Jan 18, 2011·Journal of Surgical Oncology·Haider MahdiAdnan R Munkarah
Jun 4, 2011·Gynecologic Oncology·Cecelia A PowlessWilliam A Cliby
Oct 11, 2011·Gynecologic Oncology·M KleppeR F P M Kruitwagen
Aug 7, 2012·British Journal of Cancer·T Dell' AnnaF Landoni
Jan 8, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A PereiraE Iglesias
Apr 30, 2013·PloS One·San-Gang WuXun-Xing Guan
Sep 17, 2013·PloS One·Zhenyu HeJunjie Xu
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jan 16, 2014·Gynecologic Oncology·Mauro SignorelliCostantino Mangioni
Jan 28, 2014·Journal of Surgical Oncology·Sanjay Mohanty, Karl Y Bilimoria
Aug 2, 2014·Archives of Gynecology and Obstetrics·F Zeppernick, I Meinhold-Heerlein
Oct 14, 2014·Journal of Gynecologic Oncology·Mikio Mikami
Oct 15, 2014·Gynecologic Oncology·Beyhan AtasevenAndreas du Bois
Nov 13, 2014·Japanese Journal of Clinical Oncology·Jingwei GaoYuquan Zhang
Mar 6, 2015·Journal of Cancer Research and Clinical Oncology·Cornelia BachmannEva-Maria Grischke
Apr 22, 2015·Best Practice & Research. Clinical Obstetrics & Gynaecology·Jaime Prat
Apr 29, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·X-J WuJ-F Ji
May 6, 2015·Digestive Diseases and Sciences·Chen WeiSu-Xia Luo
May 7, 2015·Histopathology·Laurice K FischerHuamin Wang
May 25, 2015·American Journal of Surgery·Marcovalerio MelisElliot Newman
Citations
Sep 12, 2013·PloS One·Michael S AnglesioDavid G Huntsman
Jun 17, 2014·PloS One·Shu Ly LimFrank Grützner
Nov 11, 2014·PloS One·Ildar V GainetdinovTatyana L Azhikina
Apr 13, 2011·Journal de gynécologie, obstétrique et biologie de la reproduction·J-M ClasseF Lécuru
Dec 1, 2017·Journal of Gynecologic Oncology·Ali AyhanMehmet Mutlu Meydanlı
May 29, 2018·Future Oncology·San-Gang WuZhen-Yu He
Aug 20, 2018·Cancer Medicine·Jieyu WangXin Lu
Jan 4, 2017·Oncotarget·Xue-Lian XuXiao-Feng Zhu
May 16, 2020·Archives of Gynecology and Obstetrics·Koray AslanAli Ayhan
Jun 12, 2020·Indian Journal of Surgical Oncology·Mohamed Ibrahim FahimRasha Mahmoud Allam
Apr 9, 2020·Frontiers in Oncology·Aoshuang Cheng, Jinghe Lang
Jun 14, 2017·Journal of Ovarian Research·Fei DengXiaoxiang Chen
May 19, 2018·World Journal of Surgical Oncology·Sarah BruggerMartin Pölcher
Apr 19, 2020·Archives of Gynecology and Obstetrics·David J NusbaumKoji Matsuo