Prognostic Value of Lymphocyte G Protein-Coupled Receptor Kinase-2 Protein Levels in Patients With Heart Failure.

Circulation Research
Giuseppe RengoDario Leosco

Abstract

Sympathetic nervous system hyperactivity is associated with poor prognosis in patients with heart failure (HF), yet routine assessment of sympathetic nervous system activation is not recommended for clinical practice. Myocardial G protein-coupled receptor kinase-2 (GRK2) is upregulated in HF patients, causing dysfunctional β-adrenergic receptor signaling. Importantly, myocardial GRK2 levels correlate with levels found in peripheral lymphocytes of HF patients. The independent prognostic value of blood GRK2 measurements in HF patients has never been investigated; thus, the purpose of this study was to evaluate whether lymphocyte GRK2 levels predict clinical outcome in HF patients. We prospectively studied 257 HF patients with mean left ventricular ejection fraction of 31.4±8.5%. At the time of enrollment, plasma norepinephrine, serum NT-proBNP, and lymphocyte GRK2 levels, as well as clinical and instrumental variables were measured. The prognostic value of GRK2 to predict cardiovascular (CV) death and all-cause mortality was assessed using the Cox proportional hazard model including demographic, clinical, instrumental, and laboratory data. Over a mean follow-up period of 37.5±20.2 months (range, 3-60 months), there were 102 CV de...Continue Reading

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Citations

May 18, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jonathan HullmannWalter J Koch
Jan 13, 2017·Cellular Signalling·Alessandro Cannavo, Walter J Koch
Nov 24, 2017·Expert Opinion on Therapeutic Targets·Alessandro CannavoGiuseppe Rengo
Apr 2, 2016·Circulation Research·Joshua G TraversBurns C Blaxall
Jun 10, 2017·Circulation Research·Ruth Williams, UNKNOWN Editors
Dec 25, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Klara KomiciGiuseppe Rengo
Aug 28, 2018·Frontiers in Pharmacology·Claudio de LuciaWalter J Koch
Mar 28, 2019·Basic Research in Cardiology·David AlujaDavid Garcia-Dorado
Jun 3, 2018·Aging Clinical and Experimental Research·Klara KomiciGiuseppe Rengo
Mar 7, 2019·Frontiers in Pharmacology·María Rodriguez-SerranoPilar D'Ocon
Feb 7, 2021·Cells·Jing ChengLinda M McAllister-Lucas
Jan 21, 2021·Cells·Marion LaudetteFrank Lezoualc'h

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