PMID: 9425325Jan 13, 1998Paper

Prognostic value of MIB-1 in advanced ovarian carcinoma as determined using automated immunohistochemistry and quantitative image analysis

Journal of Surgical Oncology
L J LayfieldB J Kerns

Abstract

The monoclonal antibody MIB-1 is an immunohistochemical marker reacting most strongly with cells in late S phase, G2, and M portions of the cell cycle. This antibody, reactive in formalin-fixed, paraffin-embedded tissue, allows the quantitation of a proliferation index (PI) in both current clinical cases and archival material using a computerized image analyzer (CIA). Since many laboratories make use of automated immunohistochemistry (AIH), this study was performed to explore the technical feasibility of using AIH (Ventana ES 320) in combination with CIA (CAS 200) to evaluate MIB-1 PI as a prognostic marker as assessed by overall survival in 50 archival (formalin-fixed, paraffin-embedded), advanced stage primary ovarian carcinomas. Exploratory methods confirmed that 15% was a cutpoint that could dichotomize these 50 patients into two prognostic groups based on overall survival. The median survival of patients whose carcinoma had a high MIB-1 expression (> or = 15%) was 16 months compared with 30 months in the patients whose tumors demonstrated low MIB-1 expression (< 15%, P = 0.01). After adjustment for age, MIB-1 retained its prognostic significance (P = 0.02). Patients 60 years and older had shorter survival than younger pati...Continue Reading

References

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Citations

Nov 8, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jonathan L HechtShelley S Tworoger
May 27, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Bernard TêtuDimcho Bachvarov
Jan 22, 2008·Pathology, Research and Practice·Andrzej SemczukElzbieta Korobowicz
May 27, 2005·The Journal of Obstetrics and Gynaecology Research·Krittaya KritprachaAlan Geater
Apr 19, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Mel C HeeranEstrid V S Høgdall
Dec 22, 1999·Gynecologic Oncology·J P GeislerW Crabtree
Jun 28, 2001·Gynecologic Oncology·W H GotliebG Ben-Baruch
Jun 22, 2005·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Ibrahim KhalifehRouba Ali-Fehmi
Apr 10, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Daniel G RosenJinsong Liu
Feb 15, 2001·Current Opinion in Obstetrics & Gynecology·J P Geisler, H E Geisler

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