Prognostic value of microRNAs in colorectal cancer: a meta-analysis

Cancer Management and Research
Song GaoZhen-Yong Zhang

Abstract

Numerous studies have shown that miRNA levels are closely related to the survival time of patients with colon, rectal, or colorectal cancer (CRC). However, the outcomes of different investigations have been inconsistent. Accordingly, a meta-analysis was conducted to study associations among the three types of cancers. Studies published in English that estimated the expression levels of miRNAs with survival curves in CRC were identified until May 20, 2017 by online searches in PubMed, Embase, Web of Science, and the Cochrane Library by two independent authors. Pooled HRs with 95% CIs were used to estimate the correlation between miRNA expression and overall survival. A total of 63 relevant articles regarding 13 different miRNAs, with 10,254 patients were ultimately included. CRC patients with high expression of blood miR141 (HR 2.52, 95% CI 1.68-3.77), tissue miR21 (HR 1.31, 95% CI 1.12-1.53), miR181a (HR 1.52, 95% CI 1.26-1.83), or miR224 (HR 2.12, 95% CI 1.04-4.34), or low expression of tissue miR126 (HR 1.55, 95% CI 1.24-1.93) had significantly poor overall survival (P<0.05). In general, blood miR141 and tissue miR21, miR181a, miR224, and miR126 had significant prognostic value. Among these, blood miR141 and tissue miR224 wer...Continue Reading

Citations

May 17, 2019·Journal of Cellular Biochemistry·Sherien M El-DalyAmira M Gamal-Eldeen
Oct 19, 2019·International Journal of Molecular Sciences·Aldona Kasprzak, Agnieszka Adamek
May 3, 2019·Expert Review of Molecular Diagnostics·Béla MolnárMagdolna Dank
Feb 6, 2020·Molecular Diagnosis & Therapy·Shanthi SabarimuruganRama Jayaraj
Jun 29, 2018·International Journal of Molecular Sciences·Rihab NasrSally Temraz
Nov 17, 2020·Frontiers in Oncology·Susana OurôCecília M P Rodrigues
Jan 26, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Pankaj AhluwaliaGagandeep K Gahlay

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