Prognostic Value of MicroRNAs in Coronary Artery Diseases: A Meta-Analysis

Yonsei Medical Journal
Ji Suk KimYun Hak Kim

Abstract

Coronary artery diseases (CADs) are the leading causes of death in the world. Recent studies have reported that differentially expressed microRNAs (miRNAs) are associated with prognosis or major adverse cardiac events (MACEs) in CAD patients. In a previous meta-analysis, the authors made serious mistakes that we aimed to correct through an updated systematic review and meta-analysis of the prognostic value of altered miRNAs in patients with CADs. We performed a systematic search of MEDLINE (from inception to May 2017) and EMBASE (from inception to May 2017) for English-language publications. Studies of CADs with results on miRNAs that reported survival data or MACEs were included. Data were extracted from each publication independently by two reviewers. After reviewing 515 articles, a total eight studies were included in this study. We measured pooled hazard ratios (HRs) and 95% confidence intervals (CIs) of miRNA 133a with a fixed-effect model (pooled HR, 2.35; 95% CI, 1.56-3.55). High expression of miRNA 133a, 208b, 126, 197, 223, and 122-5p were associated with high mortality. Additionally, high levels of miRNA 208b, 499-5p, 134, 328, and 34a were related with MACEs. The present study confirmed that miRNA 133a, which was ass...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Jul 4, 2003·The New England Journal of Medicine·Elizabeth G Nabel
May 29, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Erik A C Wiemer
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
May 13, 2009·Nature Reviews. Cardiology·Michael V G Latronico, Gianluigi Condorelli
Oct 2, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·H M HeneghanM J Kerin
Jun 10, 2010·BMC Medicine·Daniel Chan, Leong L Ng
Jun 11, 2010·European Heart Journal·Yuri D'AlessandraMaurizio C Capogrossi
Jul 3, 2010·Circulation Research·Stephan FichtlschererStefanie Dimmeler
Oct 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ngan K VoRichard H Goodman
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Masayuki KanoHisahiro Matsubara
Jun 7, 2011·Circulation. Cardiovascular Genetics·Yasuhide KuwabaraTakeshi Kimura
Aug 3, 2011·Journal of Molecular and Cellular Cardiology·Christian WideraThomas Thum
Jan 28, 2014·International Journal of Cardiology·Fabiola OlivieriAntonio Domenico Procopio
May 17, 2014·Molecular and Cellular Biochemistry·Fucheng HeShuling Dong
Jul 17, 2014·Nature Reviews. Molecular Cell Biology·Minju Ha, V Narry Kim
Apr 2, 2015·The New England Journal of Medicine·Gregory A RothChristopher J L Murray
Apr 18, 2015·International Journal of Cardiology·Wenzhai CaoQian Yu
Sep 27, 2015·Circulation·Gregory A RothChristopher J L Murray
May 4, 2016·Perspectives in Clinical Research·Ajay Francis ChristopherParveen Bansal
Sep 7, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Nuno Cortez-DiasFrancisco J Enguita
Jan 7, 2017·Oncotarget·Yun Hak KimKyoungjune Pak
Feb 9, 2017·OncoTargets and Therapy·Jiangfeng WangYufeng Cheng
May 26, 2017·Methods in Molecular Biology·Weili Huang

❮ Previous
Next ❯

Citations

Jun 4, 2020·Open Heart·Sandeep SinghSara-Joan Pinto-Sietsma
Jun 20, 2020·Therapeutic Advances in Medical Oncology·Junho KangYun Hak Kim
Jan 15, 2021·Heart Failure Reviews·Alieh GholaminejadShaghayegh Haghjooy Javanmard
Jan 25, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yudong WuDongming Xing
Nov 4, 2020·Current Pharmaceutical Design·Stavroula A PaschouDimitrios Tousoulis

❮ Previous
Next ❯

Software Mentioned

Review Manager ( RevMan
Engauge Digitizer
metafor
R
Review Manager

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.