Prognostic value of microRNAs in hepatocellular carcinoma: a meta-analysis

Oncotarget
Yue ZhangYue-Hua Jiang

Abstract

Numerous articles reported that dysregulated expression levels of miRNAs correlated with survival time of HCC patients. However, there has not been a comprehensive meta-analysis to evaluate the accurate prognostic value of miRNAs in HCC. Meta-analysis. Studies, published in English, estimating expression levels of miRNAs with any survival curves in HCC were identified up until 15 April, 2017 by performing online searches in PubMed, EMBASE, Web of Science and Cochrane Database of Systematic Reviews by two independent authors. The pooled hazard ratios (HR) with 95% confidence intervals (CI) were used to estimate the correlation between miRNA expression and overall survival (OS). 54 relevant articles about 16 miRNAs, with 6464 patients, were ultimately included. HCC patients with high expression of tissue miR-9 (HR = 2.35, 95% CI = 1.46-3.76), miR-21 (HR = 1.76, 95% CI = 1.29-2.41), miR-34c (HR = 1.64, 95% CI = 1.05-2.57), miR-155 (HR = 2.84, 95% CI = 1.46-5.51), miR-221 (HR = 1.76, 95% CI = 1.02-3.04) or low expression of tissue miR-22 (HR = 2.29, 95% CI = 1.63-3.21), miR-29c (HR = 1.35, 95% CI = 1.10-1.65), miR-34a (HR = 1.84, 95% CI = 1.30-2.59), miR-199a (HR = 2.78, 95% CI = 1.89-4.08), miR-200a (HR = 2.64, 95% CI = 1.86-3.77)...Continue Reading

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Citations

Jun 21, 2019·MicroRNA·Ioannis A ZiogasGeorgios Tsoulfas
Aug 10, 2018·Yonsei Medical Journal·Xiu Qing LinWei Wu
Mar 9, 2019·Current Drug Targets·Seyed Mostafa ParizadehAmir Avan
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Jan 6, 2019·Archives of Pharmacal Research·Mi Jeong HeoSang Geon Kim
Feb 13, 2021·Molecular Genetics and Genomics : MGG·Zhendong LiuXingyong Shen
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Aug 10, 2021·Frontiers in Cell and Developmental Biology·Duoduo LvHong Tang

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