PMID: 22567743May 10, 2012Paper

Prognostic value of miR-93 overexpression in resectable gastric adenocarcinomas

Acta Gastro-enterologica Belgica
Ling ChenHuihuan Tang

Abstract

MicroRNAs (miRNAs) have been shown to be aberrantly expressed in many human carcinomas. Emerging evidence indicates that miR-93 plays important oncogenic roles in human carcinogenesis and is often up-regulated. However, its relationship with the clinicopathological features and prognosis of human gastric cancer (GC) has yet to be addressed. In this study, we investigate the expression and clinical significance of miR-93 in human gastric cancer. 158 patients with gastric adenocarcinoma who had undergone gastrectomy were enrolled. Specimens including the tumor and non-neoplastic were detected for the expression of miR-93 by Real-Time reverse transcription-polymerase chain reaction (RT-PCR). Furthermore, the correlation of miR-93 levels with clinicopathologic variables and prognosis was analyzed. miR-93 was significantly up-regulated in 128 cases (81%) of the 158 gastric cancer (P < 0.05). Furthermore, the elevated expression of miR-93 was significantly associated with advanced disease stage (P < 0.001), deep invasion level (P < 0.001) and the presence of nodal metastases (P < 0.001). Moreover, gastric cancer patients with high miR-93 expression levels had shorter overall survival (P = 0.001) and disease-free survival (P = 0.006) ...Continue Reading

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