PMID: 3757202Aug 1, 1986Paper

Prognostic value of mitochondrial aspartate aminotransferase in acute myocardial infarction

Clinical Biochemistry
G AnnoniD Swannie

Abstract

In 112 prospectively selected patients suffering from acute myocardial infarction (AMI), the serum CK, CK-MB, LD, HBD, AST and m-AST were determined from the time of admission to hospital and every 12 hours for three days in succession. Sixteen of the enrolled patients died due to complications which arose within the first four days of hospitalization while the rest had a favourable outcome. All enzyme activities were determined at 37 degrees C using routine methods; m-AST was measured using an immunochemical method. The statistical analysis of the results demonstrated that 12 hours after admission, serum m-AST and m-AST/AST ratio were significantly higher in the group of non-survivors compared with patients with a favourable prognosis. No significant differences in CK-MB were observed between survivors and non-survivors during the entire period. True and false positive rates were calculated for these and the other enzymes. An optimum decision level of 34 IU/L was chosen for m-AST and 10% for the m-AST/AST ratio. This gave a percentage of correctly classified patients, after 12 and 24 hours, of 74.9% and 91.9%, respectively. In conclusion, the immunochemical determination of m-AST in patients with AMI seems to be an early progn...Continue Reading

References

Aug 15, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·S KameiM Yamanaka
Mar 1, 1976·Progress in Cardiovascular Diseases·G AhumadaB E Sobel
Oct 1, 1975·The American Journal of Medicine·D J BlombergM D Burke
Apr 14, 1975·JAMA : the Journal of the American Medical Association·R S GalenR Gambino
Feb 1, 1972·Zeitschrift Für Klinische Chemie Und Klinische Biochemie·G IdéoN Dioguardi
Aug 1, 1983·Archives of Internal Medicine·M L FisherG D Plotnick
Apr 27, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·S W Rabkin, P Desjardins
Dec 24, 1960·Nature·S B ROSALKI, J H WILKINSON

❮ Previous
Next ❯

Citations

Dec 15, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·F W Schmidt, E Schmidt
Dec 31, 1990·Clinica Chimica Acta; International Journal of Clinical Chemistry·N E HusebyJ Vaage
Oct 30, 1999·The Annals of Thoracic Surgery·K SuzukiH Matsuda
Aug 1, 1990·Clinical Biochemistry·M Panteghini
Sep 13, 1991·Journal of Chromatography·T MarshallK M Williams

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.