Prognostic value of mitotic counts and Ki-67 immunoreactivity in adult-type granulosa cell tumour of the ovary

Journal of Clinical Pathology
Esther LeuverinkC J R Stewart

Abstract

The identification of reliable prognostic factors in patients with ovarian stage 1 adult-type granulosa cell tumour (GCT) has proved problematic. Some reports have suggested that proliferation indices may be of value, but the data are conflicting and the methods of assessment often poorly defined. In this study the mitotic activity and Ki-67 immunohistochemistry was assessed in a series of GCT using carefully specified methodology, and the findings were correlated with clinicopathological findings. Tumour proliferation was assessed in 38 primary GCT by counting mitotic figures in 50 high-power fields (x500 magnification) with results expressed as a mean count per 2 mm(2) standardised area. The number of mitotic figures and Ki-67 immunoreactive cells per 10,000 tumour cells was also assessed using an ocular cell counting graticule. The results were correlated with tumour stage at presentation and with the development of tumour recurrence. Twenty-nine patients were stage 1 at presentation, and nine patients had high-stage disease (extra-ovarian spread). Nine patients with initial stage 1 disease developed metastases, and 20 patients had no evidence of recurrence over a mean follow-up period of 11.1 years. There was no significant...Continue Reading

Citations

Aug 22, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Colin J R StewartSukeerat Ruba
Sep 29, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Colin J R Stewart
Sep 4, 2009·Genome Medicine·Nicolas KalfaCharles Sultan
Nov 16, 2010·Annals of Diagnostic Pathology·Rania A AbadeerHuamin Wang
Feb 8, 2020·Indian Journal of Pathology & Microbiology·Prerna GuleriaSandeep R Mathur
Aug 16, 2017·Experimental and Therapeutic Medicine·Yifei LiuYe Tian
Mar 22, 2014·Molecular and Clinical Oncology·Keita KaiOsamu Tokunaga
Feb 14, 2021·Interactive Cardiovascular and Thoracic Surgery·Eva-María García-FontánUNKNOWN EMETNE members, Spanish Society of Pneumology and Thoracic Surgery

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