Prognostic value of mutational characteristics in gastrointestinal stromal tumors: a single-center experience in 275 cases

Medical Oncology
Ming WangHui Cao

Abstract

The objective of this study was to investigate the impact of KIT/PDGFRA mutations on the prognosis of gastrointestinal stromal tumors (GISTs). In the present study, genotype analyses were performed based on GIST samples from 275 patients. The relationship between mutation and clinicopathological characteristics were explored. All factors were evaluated for their impacts on relapse-free survival (RFS). Briefly, the results of genotype analyses showed that mutations were identified in 258 (93.8 %) patients, and deletion was the most frequent type of mutation accounting for 47.3 % (122/258) of all mutation cases, followed by substitution (87/258, 33.7 %) and duplication (49/258, 19.0 %). Moreover, for KIT exon 11 mutation, the most frequently involved area was from codon 557 to 560. Deep analyses showed that the mutation types were correlated with tumor location (P = 0.005), tumor size (P = 0.022), mitosis rate (P < 0.001), risk grade (P < 0.001), and relapse (P = 0.004). Furthermore, delW557-K558 correlated with mitosis rate (P = 0.042) and relapse (P = 0.036), and delTyr568/570 correlated with tumor origin (P = 0.018). Most importantly, mitotic rate [HR = 2.901 (95 % CI 1.094-7.695), P = 0.032] and risk grade [HR = 9.629 (95 % C...Continue Reading

References

Jul 3, 2002·Human Pathology·Christopher D M FletcherSharon W Weiss
Aug 15, 2003·International Journal of Cancer. Journal International Du Cancer·Eva WardelmannSabine Merkelbach-Bruse
Mar 11, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Debiec-RychterUNKNOWN EORTC Soft Tissue and Bone Sarcoma Group
May 8, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tae Won KimJung Shin Lee
Jun 30, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jean-François EmileUNKNOWN Groupe d'Etude des GIST
Sep 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher L CorlessMichael C Heinrich
Sep 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Javier MartínUNKNOWN Spanish Group for Sarcoma Research
Oct 18, 2005·Biochemical and Biophysical Research Communications·Robert Roskoski
Apr 21, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Maria Debiec-RychterUNKNOWN Australasian GastroIntestinal Trials Group
May 16, 2006·Gastroenterology·Johanna AnderssonBengt Nilsson
Sep 6, 2006·Gastroenterology·Jean-François EmileAntoinette Lemoine
May 22, 2007·Lancet·Brian P RubinChristopher L Corless
Mar 18, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ying-Yong HouAndrea Frilling
Jun 19, 2009·British Journal of Cancer·J-B BachetJ-F Emile
Jan 16, 2010·Archives of Pathology & Laboratory Medicine·Javier A Laurini, J Elliot Carter
May 18, 2010·Journal of the National Comprehensive Cancer Network : JNCCN·George D DemetriJeffrey D Wayne
Nov 11, 2010·International Journal of Cancer. Journal International Du Cancer·Gabriella ArneOla Nilsson
Apr 30, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A WozniakUNKNOWN Polish Clinical GIST Registry
May 10, 2011·Nature Medicine·Nicolas F DelahayeLaurence Zitvogel
Oct 26, 2011·Pathology, Research and Practice·Marcelle R CerskiLuise Meurer
Nov 18, 2011·Nature Reviews. Cancer·Christopher L CorlessMichael C Heinrich
Nov 29, 2011·Current Problems in Cancer·Brian Parkin, Rashmi Chugh
Mar 29, 2012·JAMA : the Journal of the American Medical Association·Heikki JoensuuPeter Reichardt
Nov 20, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·UNKNOWN ESMO / European Sarcoma Network Working Group
Oct 31, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Gabriel MinárikJozef Sufliarsky
Jan 8, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·P OrigoneG Bianchi Scarrà
May 8, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jean-Baptiste BachetJean-François Emile

❮ Previous
Next ❯

Citations

Oct 22, 2015·Scientific Reports·Anna Madej-MichniewiczWojciech Błogowski
Oct 9, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Agnieszka WozniakMaria Debiec-Rychter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
C C XiaoG X Cai
Laboratory Investigation; a Journal of Technical Methods and Pathology
S I ErnstT J O'Leary
International Journal of Colorectal Disease
Alexander BehamMichael B Ghadimi
© 2021 Meta ULC. All rights reserved