Prognostic Value of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Head and Neck Malignancies.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
Yanish Bhashkar SeetohulAshvanee Kumar Chaudhary

Abstract

To study the prognostic significance of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in head and neck cancers. The study included 170 cases of histopathologically diagnosed head and neck cancer patients and 80 control subjects. NLR and PLR of patients with head and neck cancers were compared to the control group. The correlation between NLR and PLR values and factors such as age, gender, duration of symptoms, site of tumour, histological type, histological grading, T-category, N-category and TNM stages in cancer patients were analysed. NLR and PLR were statistically higher in cancer patients compared to control. There was a non-significant increase in both NLR and PLR with advancing degree of differentiation and TNM Stages of the cancer patients. A significant increase in NLR and PLR with increasing T Categories and increasing N Categories of head and neck cancer patients was obtained. NLR and PLR can be used to estimate tumour prognosis in head and neck cancers. Increased NLR and PLR values can be used as a marker for poor prognosis. However further studies with larger study groups including treatment response and surveillance should be carried out to corroborate these results.

References

Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Aug 8, 2006·Biochemical Pharmacology·Bharat B AggarwalGautam Sethi
Mar 6, 2012·American Journal of Hematology·Alok A Khorana
Feb 3, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Mehmet DuzluRasit Cevizci

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Citations

Apr 23, 2021·Auris, Nasus, Larynx·Kohei YamaharaSatoshi Ikegami
Nov 9, 2021·Frontiers in Cardiovascular Medicine·Henrike ArfstenNoemi Pavo

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