Prognostic value of neutrophil-to-lymphocyte ratio in pulmonary arterial hypertension

The Journal of International Medical Research
Ebru ÖzpelitÖzer Badak

Abstract

To evaluate the prognostic value of baseline neutrophil-to-lymphocyte ratio (NLR) in the prediction of long-term mortality in patients with pulmonary arterial hypertension (PAH). This prospective study recorded NLR during initial diagnostic right-sided cardiac catheterization in adult patients with PAH. Demographic, clinical, laboratory and haemodynamic variables were compared by NLR tertile. Univariate and multivariate Cox regression analyses were used to determine whether NLR was independently associated with mortality. Adults with PAH (n = 101) were followed-up for mean ± SD 36.8 ± 23.6 months. The number of deaths, New York Heart Association functional capacity (NYHA FC), levels of brain natriuretic peptide (BNP) or C-reactive protein (CRP) and presence of pericardial effusion increased as the NLR tertile increased, but haemoglobin and tricuspid plane annular systolic excursion (TAPSE) decreased. On univariate analysis, high NLR values were associated with mortality, but on multivariate analysis, NLR did not remain an independent predictor of mortality. Baseline NYHA FC, TAPSE, BNP level and pericardial effusion were independent predictors of mortality. NLR was correlated with important prognostic markers in PAH such as NYH...Continue Reading

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Jul 20, 2016·International Journal of Hypertension·Mehdi MirsaeidiMicheal Campos
Jul 22, 2016·Respiratory Research·Anjum AnwarSoban Umar
Mar 21, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Yang YangRui Cheng
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Dec 14, 2018·The European Respiratory Journal·Marc HumbertMarlene Rabinovitch
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Aug 23, 2018·Frontiers in Medicine·Shalina TaylorA A Roger Thompson
Oct 28, 2020·Cells·Yijie HuNeil M Goldenberg

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Methods Mentioned

BETA
RAP
coronary bypass

Software Mentioned

SPSS®

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