Prognostic value of normal stress myocardial perfusion imaging and ventricular function in Japanese asymptomatic patients with type 2 diabetes--a study based on the J-ACCESS-2 database

Circulation Journal : Official Journal of the Japanese Circulation Society
Shinro MatsuoTsunehiko Nishimura

Abstract

This study was designed to determine the clinical risk for hard events after normal single-photon emission computed tomography (SPECT) and to identify the predictors of increased risk in asymptomatic patients with diabetes mellitus, based on a Japanese Assessment of Cardiac Events and Survival Studies by quantitative gated SPECT (J-ACCESS)-2 study. A total of 513 consecutive asymptomatic patients who underwent stress (99m)Tc-tetrofosmin SPECT in Japan were included in this study. Based on SPECT image and QGS data, 319 had a summed stress score < or =3, a summed difference score <2 and normal cardiac function (end-systolic volume < or =60 ml, males, < or =40 ml, females; left ventricular ejection fraction > or =49%, males, > or =50%, females). Myocardial perfusion was normal in 62% of this study population. During a 3-year follow-up, there were a total of 8 cardiac major events (2.5%): 2 cases of sudden death, 5 of acute coronary syndrome, and 1 of hospitalization because of congestive heart failure. The annual major event rate was 0.8%. Subjects undergoing coronary angiography had significantly more major events than those who did not among normal SPECT subjects (P=0.01). Kaplan-Meier analysis showed that the cardiac major even...Continue Reading

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Citations

Jun 14, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Wanda AcampaAlberto Cuocolo
Jul 13, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Keiichiro YoshinagaNagara Tamaki
Jul 16, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuko IgarashiAkira Yamashina
Aug 30, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Keiichiro YoshinagaNagara Tamaki
Jul 5, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Leslee J ShawAmi Iskandrian
Dec 8, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Shinro MatsuoTomoaki Nakata
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Jun 6, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Shinro Matsuo
Dec 8, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Kazuya Takehana
Feb 19, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Masakazu YamagishiUNKNOWN Japanese Circulation Society Working Group

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