Prognostic value of osteopontin expression in breast cancer: A meta-analysis

Molecular and Clinical Oncology
Ying-Yi XuYu-Qiang Chen

Abstract

Osteopontin (OPN) has been implicated in tumor development and progression over the last few years. However, the prognostic value of OPN overexpression in patients with breast cancer remains controversial. We performed a meta-analysis to investigate the association of OPN expression in the tumor with the clinicopathological characteristics and survival of breast cancer patients. A total of 8 studies met the inclusion criteria and were entered in the meta-analysis. The data analysis demonstrated that OPN expression was positively associated with lymph node metastasis [pooled odds ratio = 2.026, 95% confidence interval (CI): 1.199-3.425, P=0.008, random-effects model]. We also found that OPN expression was positively associated with overall survival [hazard ratio (HR) = 3. 69, 95% CI: 1. 45-9.42, P=0.000, random-effects model) and disease -free survival (pooled HR=2.40, 95% CI: 1.27-4.55, P=0.007, fix ed -effects model). Based on the results of this study, we concluded that OPN overexpression in the tumor is a candidate positive prognostic biomarker for breast cancer patients.

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Citations

Jul 22, 2018·Expert Opinion on Therapeutic Targets·Pieter H AnborghAnn F Chambers
Sep 28, 2018·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·A SamykuttyL R McNally
Aug 24, 2019·Scientific Reports·Tomonobu KadoKazuyuki Tobe
Oct 23, 2019·Current Obesity Reports·Gerasimos Socrates ChristodoulatosMaria Dalamaga
Oct 30, 2019·Molecular and Cellular Biology·Maria A VoronkovaYon Rojanasakul
Mar 8, 2018·International Journal of Oncology·Dalin DiJiyu Ju
Aug 16, 2016·Cell and Tissue Research·Zareen Khan, John F Marshall
Jul 28, 2016·BioMed Research International·Chengcheng HaoShan Cheng
Aug 5, 2017·Mediators of Inflammation·Luigi Mario CastelloAnnalisa Chiocchetti
Jul 18, 2020·International Journal of Molecular Sciences·Eunah Shin, Ja Seung Koo
Sep 25, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Ines BaroneSebastiano Andò

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