Prognostic value of pathologic complete response after primary chemotherapy in relation to hormone receptor status and other factors

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Valentina GuarneriAna M Gonzalez-Angulo

Abstract

To evaluate whether hormonal receptor (HR) status can influence the prognostic significance of pathologic complete response (pCR). This retrospective analysis included 1,731 patients with stage I to III noninflammatory breast cancer treated between 1988 and 2005 with primary chemotherapy (PC). Ninety-one percent of patients received anthracycline-based PC, and 66% received additional taxane therapy. pCR was defined as no evidence of invasive tumor in the breast and axillary lymph nodes. Median age was 49 years (range, 19 to 83 years). Sixty-seven percent of patients (n = 1,163) had HR-positive tumors. A pCR was observed in 225 (13%) of 1,731 patients; pCR rates were 24% in HR-negative tumors and 8% in HR-positive tumors (P < .001). A significant survival benefit for patients who achieved pCR compared with no pCR was observed regardless of HR status. In the HR-positive group, 5-year overall survival (OS) rates were 96.4% v 84.5% (P = .04) and 5-year progression-free survival (PFS) rates were 91.1% v 65.3% (P < .0001) for patients with and without pCR, respectively. For the HR-negative group, 5-year OS rates were 83.9% v 67.4% (P = .003) and 5-year PFS rates were 83.4% v 50.0% (P < .0001) for patients with and without pCR, respec...Continue Reading

References

Oct 3, 1990·Journal of the National Cancer Institute·G BonadonnaF Rilke
Mar 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T J PowlesD Cosgrove
Sep 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V F SemiglazovO F Chepic
Jul 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FisherN V Dimitrov
Aug 15, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FisherH D Bear
Mar 18, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H M KuererS E Singletary
Nov 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J A van der HageL Duchateau
Feb 6, 2003·British Journal of Cancer·I F FaneyteM J van de Vijver
Oct 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harry D BearUNKNOWN National Surgical Adjuvant Breast and Bowel Project Protocol B-27
Jun 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Allen M ChenThomas A Buchholz
Oct 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marco ColleoniAron Goldhirsch
Feb 3, 2005·Journal of the National Cancer Institute·Davide MauriJohn P A Ioannidis

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Citations

Dec 18, 2007·Breast Cancer Research and Treatment·Susanne TaucherUNKNOWN Austrian Breast and Colorectal Cancer Study Group-07
May 20, 2008·Breast Cancer Research and Treatment·Johanna G H van NesUNKNOWN Cooperating Investigators of the EORTC
Mar 1, 2012·Breast Cancer Research and Treatment·Jinjia ChangWeimin Fan
Jul 10, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Mariana Chávez-MacGregor, Ana María González-Angulo
May 21, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Marta CuadrosÁngel Concha
Jun 25, 2009·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Gumersindo Pérez MangaPilar García Alfonso
Sep 4, 2009·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Naoki WatanabeJyunji Matsuoka
Dec 9, 2010·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Hiroji Iwata
Feb 5, 2013·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Ricardo H Alvarez, Gabriel N Hortobagyi
Nov 3, 2006·Nature Clinical Practice. Oncology·Fabrice Andre, Lajos Pusztai
Mar 3, 2011·Nature Reviews. Clinical Oncology·Philippe L Bedard, Fatima Cardoso
Jun 12, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S MénardUNKNOWN OMERO Group
Feb 17, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M ColleoniA Goldhirsch
Feb 18, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C H BarriosR Caponero
Feb 18, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V GuarneriP Conte
Feb 12, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F MarméA Schneeweiss
Mar 27, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M Debled, L Mauriac
Jan 5, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L YaoY Xie
Nov 25, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M C MathieuF André
Oct 2, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·I Vaz-LuisN U Lin
Sep 26, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M Colleoni, E Montagna
Sep 26, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A Sheri, M Dowsett
Sep 26, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A M Thompson, S L Moulder-Thompson
Sep 26, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B Sousa, F Cardoso
Oct 30, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A RomeroT Caldés

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