Prognostic value of phase analysis on gated single photon emission computed tomography in patients with cardiac sarcoidosis.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Kazuhiro KoyanagawaToshihisa Anzai

Abstract

We aimed to determine the correlation between phase analysis, reflecting the heterogeneity of perfusion defects, and the dyssynchrony of the left ventricle wall motion, and adverse cardiac events in cardiac sarcoidosis (CS) patients. Fifty-seven consecutive patients with diagnosed CS (64 [IQR 55-71] years old, 14 males), who underwent 18F-FDG PET/CT and ECG-gated SPECT, were studied. FDG PET was analysed to measure cardiac metabolic volume (CMV), and total lesion glycolysis (TLG). The SPECT findings, such as LVEF, Summed Rest Score (SRS), bandwidth (BW) were evaluated. The median of BW was 56° (IQR 40-95). BW showed a strong inverse correlation with LVEF (r = - 0.60, P < 0.0001), and positive correlation with SRS (r = 0.82, P < 0.0001). However, there were no significant correlations between BW and CMV or TLG. The Kaplan-Meier curves revealed a significantly higher rate of MACE in the high BW group (BW > 56°) than the low BW group (BW ≤ 56°) (15.1%/years vs. 4.4%/years, P = 0.025). In multivariable analysis, BW was a significant independent predictor of MACE (P = 0.015). Phase analysis on gated SPECT was a significant and independent predictor of MACE in patients with CS.

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Citations

Oct 13, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Kazuhiro KoyanagawaToshihisa Anzai
Jan 28, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Thomas H SchindlerSudhir Jain
Nov 27, 2020·International Journal of Cardiology·Kyle B FrankeRajiv Mahajan

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