Prognostic value of plasma IL-27 on biological viability of hepatic cystic echinococcosis.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Shadike ApaerTuerhongjiang Tuxun

Abstract

To investigate potential biomarkers for distinguishing biological viability of hepatic cystic echinococcosis. Using Luminex assay we measured plasma concentrations of cytokine and chemokine in patients with active and non-active cysts (hepatic cystic echinococcosis (HCE), n = 47) and stable/progressive hepatic alveolar echinococcosis (HAE, n = 38), and in comparable infection-free volunteers (n = 48). Disease progression was staged according to the classification standard. Compared with healthy controls, enhanced elevation was found of T helper 22 type cytokine interleukin (IL)-22 and chemokines Eotaxin, interferon-γ inducible protein-10, monocyte chemoattractant protein-1, and stromal cell-derived factor-1α concentrations in HAE patients, and IL-22, growth-related oncogene α, monocyte chemoattractant protein-1, regulated on activation normal T-expressed and secreted, and stromal cell-derived factor-1α concentrations in HCE patients (P < 0.05-0.001). For HCE patients, only IL-27 concentrations in non-active HCE were significantly lower than in active HCE. In logistic regression analysis, IL-27 <20.79 pg/mL was an independent risk factor for HCE biological viability with receiver operating characteristic analysis at a 44.23 pg/m...Continue Reading

References

Feb 5, 2002·Immunity·Eric J Kunkel, Eugene C Butcher
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sophie LucasFrédéric J de Sauvage
Feb 3, 2005·International Journal of Cancer. Journal International Du Cancer·Masako ChiyoMasatoshi Tagawa
Jun 17, 2005·Cancer Science·Toshiyuki TanakaMasayuki Miyasaka
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshiyuki MiyazakiHiroki Yoshida
Nov 26, 2009·Acta Tropica·Enrico BrunettiUNKNOWN Writing Panel for the WHO-IWGE
Dec 20, 2011·Trends in Immunology·Elia D Tait Wojno, Christopher A Hunter
Jun 13, 2012·BMJ : British Medical Journal·Donald P McManusYurong Yang
Jul 19, 2012·Parasite Immunology·T TuxunH Wen
Nov 24, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Song ZhangZhinan Yin
Dec 19, 2012·Immunity·Christopher A Hunter, Rob Kastelein
Jun 5, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jun WeiZhinan Yin
Nov 22, 2013·Oncotarget·Purvaba J SarvaiyaMaciej S Lesniak
Dec 18, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yanhua CaoJianguo Wu
Mar 29, 2014·Parasite Immunology·S A RedpathG Perona-Wright
May 31, 2014·The Lancet Infectious Diseases·Guo-Jing YangXiao-Nong Zhou
Jul 23, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Laëtitia BassetMichel Samson
Jul 9, 2016·International Journal for Parasitology·Uriel KoziolEstela Castillo
Oct 4, 2017·Parasite : Journal De La Société Française De Parasitologie·Mei YangWenbao Zhang
Feb 15, 2019·Clinical Microbiology Reviews·Hao WenDonald P McManus
May 28, 2020·Frontiers in Immunology·Justin Komguep NonoKlaus Brehm

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