Prognostic value of plasma myeloperoxidase in ESRD patients

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Angela Yee-Moon WangJohn E Sanderson

Abstract

Myeloperoxidase (MPO) has been suggested to have a role in atherosclerosis through its strong oxidative capacity. We hypothesized that MPO level may predict clinical outcomes in patients with end-stage renal disease receiving long-term peritoneal dialysis (PD) therapy. Prospective cohort study. 236 long-term PD patients were recruited from a single regional dialysis unit in Hong Kong between April 1999 and February 2001. Level of plasma MPO, analyzed using a sandwich enzyme-linked immunosorbent assay. Mortality and fatal or nonfatal cardiovascular events at 3 years. The distribution of MPO levels was skewed with a median of 31.8 μg/L (25th-75th percentiles, 24.4-42.7). There were 69 deaths and 81 cardiovascular events. Adjusting for traditional and nontraditional risk factors and C-reactive protein, cardiac troponin T, and N-terminal pro-brain natriuretic peptide levels, a doubling in plasma MPO level was associated independently with a 46% (95% CI, 1.02-2.08; P = 0.04) and 60% (95% CI, 1.17-2.18; P = 0.003) increase in risks of mortality and cardiovascular events, respectively. Log(2)MPO showed significant additional predictive value for mortality (P = 0.04) and cardiovascular events (P = 0.005) when included in Cox regression...Continue Reading

References

Jul 1, 1992·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·K D NolphL Ponferrada
Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
Apr 1, 1984·Statistics in Medicine·F E HarrellR A Rosati
Jul 1, 1994·The Journal of Clinical Investigation·A DaughertyJ W Heinecke
Feb 1, 1994·Biological Chemistry Hoppe-Seyler·J S BeckmannC R White
May 1, 1996·Journal of the American Society of Nephrology : JASN·R W van OldenL Arisz
Jun 8, 1999·The Journal of Clinical Investigation·E A PodrezS L Hazen
Nov 25, 2000·The Journal of Biological Chemistry·H M Abu-Soud, S L Hazen
Nov 22, 2001·JAMA : the Journal of the American Medical Association·R ZhangS L Hazen
Nov 14, 2001·Free Radical Biology & Medicine·J HimmelfarbJ W Heinecke
Jun 29, 2002·Science·Jason P EiserichBruce A Freeman
Jul 5, 2002·The New England Journal of Medicine·Antonino BuffonAttilio Maseri
Oct 3, 2002·The Journal of Biological Chemistry·Renliang ZhangStanley L Hazen
Apr 16, 2003·Kidney International. Supplement·Roberto Pecoits-FilhoLouise Nordfors
Jul 9, 2003·Kidney International·Abraham RutgersJan Willem Cohen Travaert
Sep 4, 2003·Circulation·Stephan BaldusUNKNOWN CAPTURE Investigators
Oct 24, 2003·The New England Journal of Medicine·Marie-Luise BrennanStanley L Hazen
Mar 10, 2004·The American Journal of Medicine·Folkert W AsselbergsRené A Tio
Apr 9, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Chia-Chao WuYuh-Feng Lin
May 25, 2005·Circulation·Timothy S McMillenRenee C LeBoeuf
Jun 27, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kamyar Kalantar-ZadehStanley L Hazen
Dec 22, 2006·American Journal of Epidemiology·Eric Vittinghoff, Charles E McCulloch
Mar 7, 2008·Journal of the American Society of Nephrology : JASN·Angela Yee-Moon Wang, Kar-Neng Lai

❮ Previous
Next ❯

Citations

Mar 1, 2012·Seminars in Nephrology·Dinna N CruzAlan Maisel
Mar 29, 2011·Seminars in Nephrology·Angela Yee-Moon Wang
Feb 25, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Elani StrejaMoti L Kashyap
Feb 27, 2017·American Journal of Nephrology·Ivano BaragettiPaolo Fiorina
Jul 3, 2017·American Journal of Nephrology·Farsad AfshinniaUNKNOWN Michigan Kidney Translational Core CPROBE Investigator Group
Jul 6, 2014·American Journal of Physiology. Renal Physiology·Alexander LehnersUlrich Otto Wenzel
Mar 28, 2013·The Journal of Biological Chemistry·Uwe JerkeRalph Kettritz
May 3, 2019·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Cristiane RickliJosé Carlos Rebuglio Vellosa
Nov 26, 2020·The Journal of Biological Chemistry·Anna V MathewSubramaniam Pennathur
Jan 13, 2021·The Journal of Biological Chemistry·Anna V MathewSubramaniam Pennathur

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.