Prognostic value of platelet count and lymphocyte to monocyte ratio combination in stage IV non-small cell lung cancer with malignant pleural effusion

PloS One
Jeong Uk LimSang Haak Lee

Abstract

A combination of platelet and lymphocyte to monocyte ratio (LMR) (abbreviated as COP-LMR) has been recently evaluated as systemic inflammatory marker for prognostication in lung cancer. While previous study on COP-LMR has evaluated its prognostic value in NSCLC patients who underwent curative resections, the combination of these two markers has not been evaluated in advanced NSCLC yet. In this study, we evaluated the prognostic value of COP-LMR in stage IV NSCLC with malignant pleural effusion under active anticancer treatment. Between January 2012 and July 2016, 217 patients with stage IV NSCLC and MPE undergoing active anticancer treatment were selected for evaluation. If patients had both low LMR (< 2.47) and increased platelet (> 30.0 ×10(4) mm-3), they were assigned to COP-LMR group 2. Patients with one parameter were assigned to COP-LMR group 1. If none, patients were assigned to COP-LMR group 0. Median overall survival (OS) (P < 0.001), progression free survival (PFS) (P < 0.001) and histological feature (P = 0.003) showed significant differences among COP-LMR groups. For COP-LMR groups 0, 1 and 2, median survival times were 35.9, 14.7 and 7.4 months, respectively, while median progression free times were 19.2, 13.3 and ...Continue Reading

References

Jan 27, 1995·International Journal of Cancer. Journal International Du Cancer·C BellocS Menashi
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·B Felding-HabermannB M Mueller
Oct 20, 2004·British Journal of Pharmacology·Paul JuraszMarek W Radomski
Jun 14, 2008·Integrative Cancer Therapies·C Guruvayoorappan
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
Sep 26, 2008·The New England Journal of Medicine·Roy S HerbstScott M Lippman
Mar 10, 2009·Biochimica Et Biophysica Acta·Seth B CoffeltClaire E Lewis
May 12, 2009·Immunology Letters·K S Siveen, Girija Kuttan
Nov 3, 2010·Journal of Thrombosis and Haemostasis : JTH·N M Bambace, C E Holmes
Dec 16, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Dermot S O'CallaghanKenneth J O'Byrne
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sandra P D'AngeloMark G Kris
Nov 8, 2011·Clinics in Chest Medicine·Charles S Dela CruzRichard A Matthay
May 25, 2012·Journal of Surgical Oncology·Mitsuru IshizukaKeiichi Kubota
Aug 3, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·S CedrésE Felip
Jan 15, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yuankai ShiPan-Chyr Yang
Apr 23, 2014·Journal of Korean Medical Science·Kyung Hee KimSeok-Chul Yang
Mar 10, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Denis Moro-SibilotPhilipp A Schnabel
Nov 3, 2016·The Clinical Respiratory Journal·Umut Sabri KasapogluArmagan Hazar
Nov 8, 2017·Allergologia et immunopathologia·S Scheurer, M Toda

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Citations

May 12, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jonathan Caleb QuekDevanand Anantham
Mar 25, 2019·Oncoimmunology·Pranav MurthyMichael T Lotze

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Methods Mentioned

BETA
biopsy
PCR
surgical resection

Software Mentioned

Statistical Package for Social Sciences

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