Prognostic value of postoperative proteinuria in cardiac surgery: a pilot study

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Keyvan KarkoutiW Scott Beattie

Abstract

Proteinuria is a non-specific marker of inflammation that may reflect the glomerular component of systemic capillary leak. The objective of this pilot study was to determine if postoperative proteinuria is associated with adverse outcomes following cardiac surgery with cardiopulmonary bypass. Eligible patients were individuals undergoing cardiac surgery with cardiopulmonary bypass who did not have severe pre-existing renal dysfunction. Urine was collected after induction of anesthesia (baseline) and two to four hours after arrival to the intensive care unit (ICU). Proteinuria was measured as random protein creatinine ratio in g.mol(-1). Adverse events were defined a priori as prolonged ICU stay (> or = 90th percentile) and organ dysfunction. The relationship between proteinuria and adverse events was assessed by bivariate (Chi-square or Fisher's exact tests) and multivariable (multiple logistic regression) analyses. The study included 197 (of 243 eligible) patients. Postoperative proteinuria (protein creatinine ratio > or = 30 g.mol(-1)) was associated with prolonged (> or = four days) ICU stay [odds ratio (OR) 7.0; 95% confidence interval (CI) 2.8-17.1] and organ dysfunction (OR 3.9; CI 1.9-8.1). After adjustment for confounde...Continue Reading

References

Aug 1, 1995·European Journal of Clinical Investigation·J S JensenB Feldt-Rasmussen
Feb 5, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·D PaparellaE Young
Jun 29, 2002·Journal of the American Academy of Nurse Practitioners·Mary Jo Goolsby
Apr 12, 2003·Critical Care Medicine·Natalya ThorevskaYaw Amoateng-Adjepong
May 4, 2005·Journal of Cardiothoracic and Vascular Anesthesia·C Scott BrudneyMav Manji
Mar 11, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Keyvan KarkoutiW Scott Beattie

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