Abstract
The predictive value of pre-autologous stem cell transplantation (pre-ASCT) positron emission tomography/computed tomography (PET/CT) scans according to different criteria remains elusive in patients with diffuse large B-cell lymphoma (DLBCL). A total of 46 DLBCL patients treated with pre-ASCT were enrolled in the present study, and two methods, Deauville score and maximal standardized uptake value reduction (ΔSUVmax), were used to evaluate the PET/CT scans before transplantation. In patients with Deauville 1-3 and ≥4, the 2-year progression-free survival (PFS) rates were 82.8 and 11.8% (p < 0.001), respectively, while the 2-year overall survival (OS) rates were 89.7 and 41.2%, respectively (p < 0.001). When using the ΔSUVmax cut-off of 66% criterion, in patients with a ΔSUVmax of >66 and ≤66%, the 2-year PFS rates were 78.1 and 7.1%, respectively (p < 0.001), while the 2-year OS rates were 87.5 and 35.7%, respectively (p < 0.001). In the univariate analysis, the ΔSUVmax, Deauville score, NCCN-IPI and serum lactate dehydrogenase levels were significantly correlated with the 2-year PFS/OS. Furthermore, the multivariate analysis revealed that the Deauville score was an independent prognostic factor for 2-year PFS. The present res...Continue Reading
References
Dec 7, 1995·The New England Journal of Medicine·T PhilipJ L Harousseau
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN International Non-Hodgkin's Lymphoma Prognostic Factors Project
May 15, 2007·Cancer·Elias JabbourLuis Fayad
Jul 12, 2007·Cancer·Jean-Emmanuel FilmontNicolas Mounier
Oct 4, 2008·Cancer·Enrico DerenziniPier Luigi Zinzani
Feb 4, 2010·Blood·Jonathan R LambertStephen Mackinnon
Nov 27, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Hélène MonjanelUNKNOWN GOELAMS
Apr 27, 2011·Blood·René-Olivier CasasnovasUNKNOWN Groupe d'étude des lymphomes de l'adulte (GELA)
Apr 13, 2013·The Lancet Oncology·Richard DelarueAndré Bosly
May 8, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Emmanuel IttiCorinne Haioun
Aug 10, 2013·Leukemia & Lymphoma·Nathalie NolsEric Van Den Neste
Dec 18, 2013·International Journal of Hematology·Shojiro InanoNobuyoshi Arima
Feb 19, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Craig S SauterCraig H Moskowitz
Jul 22, 2014·The Lancet Oncology·Anas YounesYasuhiro Oki
Aug 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonT Andrew Lister
Mar 12, 2015·Blood·Craig S SauterCraig H Moskowitz
Jun 3, 2015·Radiology·Gary A UlanerAndrew D Zelenetz
Jan 21, 2017·British Journal of Haematology·Carlos MontalbánUNKNOWN GELTAMO-IPI Project Investigators
Apr 6, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A YounesV E Seshan
May 16, 2017·The American Journal of the Medical Sciences·Yan YangMei Huang
Jul 14, 2017·Blood·R-O CasasnovasF Morschhauser
Aug 31, 2017·Leukemia & Lymphoma·Allison WinterBrian T Hill
Nov 12, 2017·Clinical Lymphoma, Myeloma & Leukemia·Fernando Cabanillas, Bijal Shah
Jan 23, 2018·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Zhitao YingJun Zhu